8p9k: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 8p9k is ON HOLD
+==Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB503==
+<StructureSection load='8p9k' size='340' side='right'caption='[[8p9k]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
-Authors: Balourdas, D.I., Bauer, N., Knapp, S., Joerger, A.C., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8p9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P9K FirstGlance]. <br>
-Description: Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB503
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X9U:~{N}-(2-azanyl-5-phenyl-phenyl)-4-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)benzamide'>X9U</scene></td></tr>
-[[Category: Knapp, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p9k OCA], [https://pdbe.org/8p9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p9k RCSB], [https://www.ebi.ac.uk/pdbsum/8p9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p9k ProSAT]</span></td></tr>
-[[Category: Balourdas, D.I]]
+</table>
-[[Category: Joerger, A.C]]
+== Disease ==
-[[Category: Structural Genomics Consortium (Sgc)]]
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-[[Category: Bauer, N]]
+== Function ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Balourdas DI]]
+[[Category: Bauer N]]
+[[Category: Joerger AC]]
+[[Category: Knapp S]]