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*'''Pro-phosphlipase (PPLA2)''' is a pancreatic PLA2 whose 7-mer N-terminal peptide is cleaved off to produce the active PLA2.<br />
*'''Pro-phosphlipase (PPLA2)''' is a pancreatic PLA2 whose 7-mer N-terminal peptide is cleaved off to produce the active PLA2.<br />
*For details on Lys49 snake-venom PLA2 see [[Anum-II]].<br />
*For details on Lys49 snake-venom PLA2 see [[Anum-II]].<br />
*For PLA2 inhibitor see [[Atropine]]<br />
*See also [[Phospholipase (Hebrew)]].
*See also [[Phospholipase (Hebrew)]].


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shows three mail helices in phospholipase A2.  
shows three mail helices in phospholipase A2.  
The <scene name='Diclofenac_binding_to_Phospholipase_A2/Active_site/2'>active site residues</scene> are His 48, Asp 49, Tyr 52 and Glu 99 in the structure.  
The <scene name='Diclofenac_binding_to_Phospholipase_A2/Active_site/2'>active site residues</scene> are His 48, Asp 49, Tyr 52 and Glu 99 in the structure.  
Diclofenac makes several <scene name='Diclofenac_binding_to_Phospholipase_A2/Hydro/1'>Hydrophobic interactions</scene> with the substrate binding site of enzyme. ligand binding is shown in <scene name='Diclofenac_binding_to_Phospholipase_A2/Space_filling/1'>space filling</scene> model of the complex.
Diclofenac makes several <scene name='Diclofenac_binding_to_Phospholipase_A2/Hydro/1'>Hydrophobic interactions</scene> with the substrate binding site of enzyme. ligand binding is shown in <scene name='Diclofenac_binding_to_Phospholipase_A2/Space_filling/1'>space filling</scene> model of the complex. See also [[Diclofenac]].


== Crystal structure of porcine pancreatic phospholipase A<sub>2</sub> in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione ==
== Crystal structure of porcine pancreatic phospholipase A<sub>2</sub> in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione ==
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Removing the labels, atropine can be seen making contact with the atoms emphasized by the space filling model, interacting with the <scene name='Sandbox_53/Phospholipase2a_interactions/1'>active site</scene> of phospholipase 2A through white as-tricks.
Removing the labels, atropine can be seen making contact with the atoms emphasized by the space filling model, interacting with the <scene name='Sandbox_53/Phospholipase2a_interactions/1'>active site</scene> of phospholipase 2A through white as-tricks.
</StructureSection>


== 3D Structures of Phospholipase A2 ==
== 3D Structures of Phospholipase A2 ==
[[Phospholipase A2 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Phospholipase A2
 
**[[1une]], [[1mkt]], [[1irb]], [[1bp2]], [[1bpq]], [[1g4i]], [[2bp2]], [[2bpp]] - bPLA2 – bovine<br />
**[[2zp3]], [[2zp4]], [[2zp5]], [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]], [[1mks]], [[1mku]], [[1vkq]], [[1vl9]], [[2bax]], [[2bch]], [[2bd1]], [[1o3w]], [[1gh4]] – bPLA2 (mutant) – bovine<br />
**[[1bvm]] – bPLA2 - NMR<br />
**[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
**[[2qog]] – PLA2 – ''Crotalus durissus''<br />
**[[2ph4]] – PLA2 – ''Zhaoermia mangshanensis''<br />
**[[2h4c]], [[1q6v]] – IvPLA2 – Indian viper<br />
**[[1vpi]] – PLA2 – sand viper<br />
**[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
**[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
**[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
**[[1p2p]], [[4p2p]] – pPLA2 - pig<br />
**[[1y6p]], [[2phi]], [[3p2p]]  – pPLA2 (mutant) – pig<br />
**[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
**[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />
**[[1oz6]], [[2qhe]] – PLA2 – ''Echis carinatus''<br />
**[[1it4]], [[1it5]] – PLA2 – Stretomyces violaceoruber – NMR<br />
**[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
**[[1s8g]], [[1s8h]], [[1s8i]] – PLA2 – copperhead<br />
**[[1ijl]] – PLA2 – ''Deinagkistrodon acutus''<br />
**[[1mc2]], [[4hg9]] – PLA2 – Chinese moccasin<br />
**[[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]] – bPLA2 (mutant) – bovine<br />
**[[1b4w]], [[1jia]], [[1c1j]] – AhPLA2 - ''Agkistrodon halys''<br />
**[[1a2a]], [[1m8r]], [[1m8s]], [[1psj]] – PLA2 – ''Gloydius halys''<br />
**[[1a3d]], [[1a3f]], [[1ln8]], [[1mh2]], [[1mh8]], [[1ows]], [[1poa]], [[1psh]], [[1s6b]], [[1sz8]], [[1xxw]], [[1y75]], [[1yxl]], [[1yxh]] – PLA2 – ''Naja naja''<br />
**[[1mh7]] - PLA2 – ''Naja sagittifera''<br />
**[[2osh]] – PLA2 – Chinese cobra<br />
**[[1ae7]], [[2not]], [[4e4c]] – PLA2 – ''Notechis scutatus''<br />
**[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – ''Vipera ammodytes''<br />
**[[2i0u]] – PLA2 – ''Vipera nikolskii''<br />
**[[1ayp]], [[1bbc]], [[1pod]] – hPLA2 – human<br />
**[[1rlw]] – hPLA2 CALB domain<br />
**[[1faz]], [[1kp4]] – PLA2 – ''Streptomyces violaceruber''<br />
**[[1god]] – PLA2 – ''Cerrophidion godmani''<br />
**[[1gp7]], [[1m8t]] – PLA2 – ''Ophiophagus hanna''<br />
**[[1ozy]], [[1p7o]], [[1pwo]] – PLA2 – ''Micropechis ikahena''<br />
**[[1pp2]] – PLA2 – rattlesnake<br />
**[[1ppa]], [[1vap]] – PLA2 – cottonmouth<br />
**[[1u4j]] – PLA2 – ''Bungarus caeruleus''<br />
**[[2aoz]] – PLA2 – ''Atropoides nummifer''<br />
**[[3v9m]] – PLA2 – king brown snake<br />
 
*Phospholipase A2  group I
 
**[[3elo]] – hPLA2G1B<br />
**[[3q4y]] - PLA2G1 - Andaman cobra <br />
**[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br />
**[[3qlm]] - pPLA2G1B + hexadecanoic acid<br />
**[[3l30]], [[4dbk]] - pPLA2G1B+berberine derivative<br />
**[[4g5i]] – pPLA2 + DBP<br />
**[[4o1y]] – pPLA2 + naphthalene acetic acid<br />
**[[3osh]] – NnPLA2G1+atropine
 
*Phospholipase A2  group II
 
**[[1j1a]], [[3u8b]] – hPLA2G2A<br />
**[[1n28]], [[1n29]] – hPLA2G2A (mutant)<br />
**[[1cl5]], [[1fb2]], [[1vip]], [[2pvt]], [[2pyc]], [[5vet]] – DrPLA2 – ''Daboia russellii''<br />
**[[2qhw]] – DrPLA2 + gramine derivative<br />
**[[2que]] – DrPLA2 + ajamaline + anisic acid<br />
**[[1kqu]], [[1kvo]] – hPLA2G2A+substrate analog<br />
**[[3u8d]], [[3u8h]], [[3u8i]], [[4hmb]] - hPLA2G2A + inhibitor<br />
**[[5g3n]] - hPLA2G2A (mutant) + inhibitor<br />
**[[5wzw]], [[5wzv]], [[5wzu]], [[5wzt]], [[5wzs]], [[5wzo]], [[5wzm]] - hPLA2G2E + inhibitor<br />
**[[5yse]] - hPLA2G2E (mutant) + inhibitor<br />
**[[3g8f]] – DrPLA2G2+polypeptide<br />
**[[3mlm]] – PLA2G2 + myristic acid – ''Neuwiedi lancehead''<br />
**[[4fga]], [[4gfy]], [[4gld]] – DrPLA2 + polypeptide
 
*Human PLA2 group IVd
**[[5iz5]] – hPLA2GIVd <br />
**[[5ixc]], [[5izr]] – hPLA2GIVd + fluorophosphonate derivative<br />
 
*Phospholipase A2  group V
 
**[[4rfp]] – PLA2 – chinese green tree viper
 
*Human phospholipase A2  group X
 
**[[1le6]], [[1le7]], [[4uy1]], [[5g3m]] – hPLA2G10<br />
**[[5owc]], [[5ow8]] - hPLA2G10 + inhibitor<br />
 
*Human phospholipase A2 group XV
 
**[[4x90]] – hPLA2G15<br />
**[[4x92]] – hPLA2G15 (mutant)<br />
**[[4x91]] – hPLA2G15 + IDFP<br />
**[[4x93]], [[4x94]], [[4x95]], [[4x97]] – hPLA2G15 + arachidonyl derivative<br />
 
*Human phospholipase A2  group XVI
 
**[[2kyt]], [[4dot]], [[4fa0]] – hPLA2G16 N-terminal<br />
 
*Phospholipase A2  group XIII
 
**[[4aup]] – PLA13 – whitish truffle
 
*Phospholipase A2 +inhibitor
 
**[[3o4m]], [[3hsw]] – PLA2+inhibitor <br />
**[[2azy]], [[2azz]], [[2b00]], [[2b01]], [[2b03]], [[2b04]]  – pPLA2+cholate derivative<br />
**[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
**[[1l8s]] – pPLA2+LPC-ether<br />
**[[5p2p]] – pPLA2+substrate analog<br />
**[[3nju]] – PLA2 group I+4-methoxy-benzoic acid – Andaman cobra<br />
**[[2wq5]] – PLA2+minocyclin – Indian cobra<br />
**[[1oxl]] – IcPLA2+indole<br />
**[[3h1x]], [[3fo7]] – IvPLA2+indomethacin <br />
**[[3fg5]] – IvPLA2+pentapeptide+ajmaline<br />
**[[3cbi]] – IvPLA2+anisic acid+ajmaline<br />
**[[2qu9]] – IvPLA2+eugenol<br />
**[[2otf]] – IvPLA2+atenolol<br />
**[[1zwp]] -  IvPLA2+nimesulide<br />
**[[1th6]] -  IvPLA2+atropine<br />
**[[1td7]] -  IvPLA2+niflumic acid<br />
**[[1tgm]] -  IvPLA2+aspirin<br />
**[[2wg9]] – rPLA2+octanoic acid<br />
**[[1oxr]] – NsPLA2+aspirin<br />
**[[1bk9]] – AhPLA2+PBPB<br />
**[[1fdk]] – bPLA2+MJ33<br />
**[[1mkv]] – bPLA2+transition state analog<br />
**[[1o2e]] – bPLA2 (mutant)+anisic acid<br />
**[[2b96]] - bPLA2+benzoic acid derivative<br />
**[[3bp2]] – bPLA2+pyruvic acid<br />
**[[1pob]] - NnPLA2+transition state analog<br />
**[[1poc]] - PLA2+transition state analog – Honey bee<br />
**[[1db4]], [[1db5]], [[1dcy]] – hPLA2+indole<br />
**[[1poe]] – hPLA2+phosphonyl inhibitor<br />
**[[1fv0]] – DrPLA2+aristolochic acid<br />
**[[1sv3]] - DrPLA2+benzoic acid derivative<br />
**[[1tp2]], [[2pws]], [[2q1p]] – DrPLA2+fatty acid<br />
**[[1sv9]], [[1sxk]], [[1zyx]], [[2b17]], [[2qvd]] – DrPLA2+anti-inflammatory agent<br />
**[[1kpm]] – DrPLA2+vitamin E<br />
**[[1oyf]] – DrPLA2+venom-6 methyl-heptanol<br />
**[[1q7a]] – DrPLA2+oxyphenabutazone<br />
**[[1y38]] – DrPLA2+glycerophosphate<br />
**[[1zr8]] – DrPLA2+ajmaline<br />
**[[2arm]] – DrPLA2+atropine<br />
**[[2dpz]] – DrPLA2 +hydroxyphenyl acetamide<br />
**[[2oli]], [[2oth]], [[2oyf]] – DrPLA2+indole derivative<br />
**[[2oub]] – DrPLA2+atenolol<br />
**[[4qem]] – DrPLA2 + coumaric acid<br />
**[[4qer]] – DrPLA2 + resveratrol<br />
**[[4qf7]] – DrPLA2 + corticosterone<br />
**[[4qf8]] – DrPLA2 + spermidine<br />
**[[4qgd]] – DrPLA2 + gramine derivative<br />
**[[4qmc]] – DrPLA2 + biotin derivative<br />
**[[2pmj]] – DrPLA2+benzopyrone<br />
**[[2zbh]] – DrPLA2+bavachalcone<br />
**[[4eix]] - DrPLA2+indomethacin + nimesulide<br />
**[[1po8]], [[1tc8]] – kPLA2+fatty acid<br />
**[[1xxs]] – PLA2+fatty acid – ''Bothrops moojeni''<br />
**[[2qhd]] – EcPLA2+fatty acid<br />
**[[3bjw]] – EcPLA2+suramin<br />
**[[1y4l]] – PLA2+suramin – ''Bothrops asper''
 
*Phospholipase A2 +polypeptide
 
**[[2o1n]], [[2d02]], [[2fnx]], [[1zm6]], [[1tdv]], [[1tg4]], [[1t37]] -  IvPLA2+polypeptide<br />
**[[1jq8]], [[1jq9]] - DsPLA2+polypeptide<br />
**[[1mf4]], [[2rd4]], [[3gci]], [[3jq5]], [[3jql]], [[3jti]] - NnPLA2+polypeptide<br />
**[[1skg]], [[1sqz]], [[1tg1]], [[1tj9]], [[1tjk]], [[1tk4]], [[2do2]], [[2g58]], [[2gns]], [[2pb8]] - DrPLA2+polypeptide
 
*Lp-PLA2
 
**[[1wab]] – bLP-PLA2 + acetate <br />
**[[1bwp]], 1bwq]], 1bwr]], 1es9]] – bLP-PLA2 ( mutant) <br />
**[[1fxw]] – bLP-PLA2 β + γ subunits<br />
**[[1uuj]] - mLP-PLA2 α subunit N terminal – mouse<br />
**[[1vyh]] - mLP-PLA2 α subunit C terminal + β subunit<br />
**[[3d59]] – hLP-PLA2 residues 47-429 <br />
*Lp-PLA2 binary complexes
**[[3dt6]] - bLP-PLA2 α subunit (mutant) + paraoxon<br />
**[[3dt8]] - bLP-PLA2 α subunit (mutant) + sarin<br />
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />
**[[3d5e]] - hLP-PLA2 residues 47-429 + paraoxon<br />
**[[3f96]] - hLP-PLA2 residues 47-429 + sarin<br />
**[[3f97]] - hLP-PLA2 residues 47-429 + soman<br />
**[[3f98]] - hLP-PLA2 residues 47-429 + tabun<br />
**[[3f9c]] - hLP-PLA2 residues 47-429 + DFP<br />
**[[5i8p]], [[5i9i]], [[5jad]], [[5jah]], [[5jal]], [[5jan]], [[5jao]], [[5jap]], [[5jar]], [[5jas]], [[5jat]], [[5jau]], [[5lp1]], [[5lz2]], [[5lz8]], [[5lz9]] - hLP-PLA2 residues 47-429 + inhibitor<br />
**[[5lyy]], [[5lz4]], [[5lz5]], [[5lz7]] - hLP-PLA2 residues 47-429 (mutant) + inhibitor<br />
 
*Bothrops toxins
 
**[[3i3h]], [[3i3i]], [[3hzd]], [[2oqd]], [[1zlb]], [[1umv]], [[1u73]], [[1zl7]]  – BTX<br />
**[[3jr8]] – BTXD+Ca<br />
**[[3hzw]], [[3i03]] – BTX+BPB<br />
**[[3iq3]], [[2h8i]] – BTX + PEG<br />
**[[1z76]] – BTX+bromophenacyl<br />
**[[1gmz]], [[1qll]], [[2q2j]], [[2ok9]]  - PTX<br />
**[[3cyl]], [[3cxi]] – PTX+a-tocopherol<br />
**[[2oqd]], [[3jr8]] – BTX-II<br />
 
*Viperotoxin
 
**[[1oqs]] – DrRV4/RV7
 
*cPhospholipase A2
 
**[[1cjy]] - h-cPLA2<br />
**[[1bci]] – h-cPLA2 C2 domain
 
*Pro-Phospholipase A2


**[[1hn4]] – pPPLA2+MJ33<br />
**[[4bp2]] – bPPLA2
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman
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