5dx5: Difference between revisions

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 ==Crystal structure of methionine gamma-lyase from Clostridium sporogenes==
-<StructureSection load='5dx5' size='340' side='right' caption='[[5dx5]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
+<StructureSection load='5dx5' size='340' side='right'caption='[[5dx5]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5dx5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DX5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5dx5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_sporogenes Clostridium sporogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DX5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_gamma-lyase Methionine gamma-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.11 4.4.1.11] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dx5 OCA], [http://pdbe.org/5dx5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dx5 RCSB], [http://www.ebi.ac.uk/pdbsum/5dx5 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dx5 OCA], [https://pdbe.org/5dx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dx5 RCSB], [https://www.ebi.ac.uk/pdbsum/5dx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dx5 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/J7TA22_CLOS1 J7TA22_CLOS1]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes the gamma-elimination reaction of L-methionine. The enzyme is a promising target for therapeutic intervention in some anaerobic pathogens and has attracted interest as a potential cancer treatment. The crystal structure of MGL from Clostridium sporogenes has been determined at 2.37 A resolution. The fold of the protein is similar to those of homologous enzymes from Citrobacter freundii, Entamoeba histolytica, Pseudomonas putida and Trichomonas vaginalis. A comparison of these structures revealed differences in the conformation of two flexible regions of the N- and C-terminal domains involved in the active-site architecture.
+Structure of methionine gamma-lyase from Clostridium sporogenes.,Revtovich S, Anufrieva N, Morozova E, Kulikova V, Nikulin A, Demidkina T Acta Crystallogr F Struct Biol Commun. 2016 Jan 1;72(Pt 1):65-71. doi:, 10.1107/S2053230X15023869. Epub 2016 Jan 1. PMID:26750487<ref>PMID:26750487</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 5dx5" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Methionine gamma-lyase 3D structures|Methionine gamma-lyase 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Methionine gamma-lyase]]
+[[Category: Clostridium sporogenes]]
-[[Category: Anufrieva, N V]]
+[[Category: Large Structures]]
-[[Category: Demidkina, T V]]
+[[Category: Anufrieva NV]]
-[[Category: Morozova, E A]]
+[[Category: Demidkina TV]]
-[[Category: Nikulin, A D]]
+[[Category: Morozova EA]]
-[[Category: Revtovich, S V]]
+[[Category: Nikulin AD]]
-[[Category: Clostridium sporogene]]
+[[Category: Revtovich SV]]
-[[Category: Lyase]]