Naproxen: Difference between revisions
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<StructureSection load='3nt1' size='350' side='right' caption='COX-2 Naproxen Complex ([[3nt1]])' scene=''> | |||
[[Naproxen]] '''Sodium''' is a '''nonsteroidal anti-inflammatory drug''' ('''NSAID''') that can be prescribed to relieve [[inflammation]], stiffness, tenderness, or pain that can be caused by:<ref>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000526/</ref> | [[Naproxen]] '''Sodium''' is a '''nonsteroidal anti-inflammatory drug''' ('''NSAID''') that can be prescribed to relieve [[inflammation]], stiffness, tenderness, or pain that can be caused by:<ref>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000526/</ref> | ||
*Osteoarthritis | *Osteoarthritis | ||
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==Naproxen In Vivo== | ==Naproxen In Vivo== | ||
Although Naproxen has been on the market for a number of years, little is known about its method of inhibition. While researchers have recently discovered how naproxen binds to the COX-2 enzyme, they have not yet been able to prove how this inhibits the enzyme’s function. | Although Naproxen has been on the market for a number of years, little is known about its method of inhibition. While researchers have recently discovered how naproxen binds to the COX-2 enzyme, they have not yet been able to prove how this inhibits the enzyme’s function. | ||
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While how naproxen binds to COX-2 was | While how naproxen binds to COX-2 was discovered in September of 2010, no breakthroughs have yet been make as to how or why naproxen binding inhibits enzyme function. <scene name='42/420810/Binding_site/3'>Naproxen binding site</scene> ([[3nt1]]). | ||
[[Image:Mechanism naproxen.jpg]]<ref>http://www.pdb.org/pdb/explore/explore.do?structureId=3NT1</ref> | [[Image:Mechanism naproxen.jpg]]<ref>http://www.pdb.org/pdb/explore/explore.do?structureId=3NT1</ref> | ||
==Additional Resources== | ==Additional Resources== | ||
For Additional Information, See [[Pharmaceutical Drugs]] | For Additional Information, See [[Pharmaceutical Drugs]] | ||
</StructureSection> | |||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||