Lysophosphatidic acid receptor: Difference between revisions
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{{BAMBED | |||
|DATE=June 14, 2016 | |||
|OLDID=2607465 | |||
|BAMBEDDOI=10.1002/bmb.21026 | |||
}} | |||
==Lysophosphatidic Acid Receptor 1== | ==Lysophosphatidic Acid Receptor 1== | ||
<StructureSection load=' | <StructureSection load='' size='340' side='right' caption='Cartoon representation of the LPA1 protein and its antagonist, ON7, colored in white. ([https://en.wikipedia.org/wiki/Protein_Data_Bank PDB] code [http://www.rcsb.org/pdb/explore/explore.do?structureId=4z34 4Z34]) ' scene='72/721545/Overall/2'> | ||
== Introduction == | == Introduction == | ||
'''Lysophosphatidic Acid Receptor''' 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phosphate receptors.<ref name="regpeps"/> LPA<sub>1</sub> is responsible for initiating several different signaling cascades with different molecules and G-proteins.<ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref> These cascades ultimately result in growth, survival, and movement of cells, as well as neural cell development.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref> | '''Lysophosphatidic Acid Receptor''' 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). These receptors bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family], which includes the more widely studied sphingosine 1-phosphate receptors.<ref name="regpeps"/> LPA<sub>1</sub> is responsible for initiating several different signaling cascades with different molecules and G-proteins.<ref name = 'Yung'>Yung, Y. C., N. C. Stoddard, and J. Chun. "LPA Receptor Signaling: Pharmacology, Physiology, and Pathophysiology." The Journal of Lipid Research 55.7 (2014): 1192-214. Web. 17 Feb. 2016.' </ref> These cascades ultimately result in growth, survival, and movement of cells, as well as neural cell development.<ref name = 'Chun'>Chun, J., Hla, T., Spiegel, S., and Moolenaar, W.H. “Lysophospholipid Receptors: Signaling and Biochemistry.” John Wiley & Sons, Inc. (2013) pp.i-xviii. 5 Feb. 2016.' </ref> | ||
See also | |||
*[[Lipid signaling]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
[[Image:LPA_in_membrane4.fw.png|200px|center|thumb|'''Figure 1:''' LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.]] | [[Image:LPA_in_membrane4.fw.png|200px|center|thumb|'''Figure 1:''' LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.]] | ||
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==3D structures of lysophosphatidic acid receptor== | ==3D structures of lysophosphatidic acid receptor== | ||
[[4z34]], [[4z35]], [[4z36]] - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[4z34]], [[4z35]], [[4z36]] - hLPA1 + antagonist - human<br /> | |||
[[2lq4]] – hLPA1 second extracellular loop – NMR<br /> | |||
[[4p0c]] – hLPA2/NHERF2<br /> | |||
[[7td0]], [[7td1]], [[7td2]] – hLPAR1 + GI complex + LPA – Cryo EM<br /> | |||
[[7yu5]] – hLPAR1 + GI complex + scFv + agonist – Cryo EM<br /> | |||
[[7yu3]], [[7yu6]], [[7yu7]], [[7yu8]] – hLPAR1 + GI complex + scFv + LPA derivative – Cryo EM<br /> | |||
[[7yu4]] – hLPAR1 + LPA derivative – Cryo EM<br /> | |||
[[5xsz]] – LPA6A (mutant) – zebra fish<br /> | |||
== References == | == References == | ||
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[http://proteopedia.org/wiki/index.php/User:R._Jeremy_Johnson/CH462:Biochemistry_II_Butler_University Butler University Proteopedia Pages] | [http://proteopedia.org/wiki/index.php/User:R._Jeremy_Johnson/CH462:Biochemistry_II_Butler_University Butler University Proteopedia Pages] | ||
See also: | |||
*[[Receptor]] | |||
*[[Transmembrane (cell surface) receptors]] | |||
*[[G protein-coupled receptors]] | |||
</StructureSection> | </StructureSection> | ||
==Student Contributors== | ==Student Contributors== | ||
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Clayton Taylor | Clayton Taylor | ||
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