Lysin: Difference between revisions

Latest revision as of 13:34, 18 June 2023

Function

Lysin (Lys) is a protein which cleaves cell walls. Egg Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg.

Structural highlights

The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic molecule. . you can see the alpha helixes in pink. exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of ,(in green) and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action^[1].

3D structure of lysin

Lysin 3D structures

ReferencesReferences

↑ Shaw A, McRee DE, Vacquier VD, Stout CD. The crystal structure of lysin, a fertilization protein. Science. 1993 Dec 17;262(5141):1864-7. PMID:8266073

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Carmit Ginesin, Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

[1] Shaw A, McRee DE, Vacquier VD, Stout CD. The crystal structure of lysin, a fertilization protein. Science. 1993 Dec 17;262(5141):1864-7. PMID:8266073

[1]

@@ Line 8: / Line 8: @@
 == 3D structure of lysin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1lis]], [[1lyn]], [[2lis]], [[2lyn]], [[3lyn]], [[5ii7]], [[5ii8]], [[5ii9]] – aLys - abalone<br />
+[[Lysin 3D structures]]
-[[5utg]] – aLys (mutant)<br />
-[[5iia]], [[5iib]], [[5mr3]] – aLys + vitelline envelope sperm lysin receptor<br />
-[[1nkl]] – NK-Lys – pig – NMR<br />
-[[4cvd]] – Lys – bacteriophage CP-7<br />
-[[6ilu]] – Lys – bacteriophage PBC5<br />
-[[5kgr]], [[6ist]], [[6l00]] – EpLys – Enterococcus phage IMEEF1<br />
-[[5jgr]], [[7dws]] – T4Lys – Enterobacteria phage T4<br />
-[[4w51]], [[4w52]], [[4w53]], [[4w54]], [[4w55]], [[4w56]], [[4w57]], [[4w58]], [[4w59]], [[5jgn]], [[5jgt]], [[5jgu]], [[5jgv]], [[5jgx]], [[5jgz]], [[5lwo]], [[5nx0]] – T4Lys (mutant) <br />
-[[5g27]], [[5jws]], [[5jwt]], [[5jwu]], [[5jwv]], [[5jww]] – T4Lys (mutant) + azaborine <br />
-[[1h09]] – bLys – bacteriophage CP-1<br />
-[[1oba]] – bLys + choline<br />
-[[2ixu]] – bLys + peptidoglycan analog<br />
-[[2ixv]], [[2j8f]], [[2j8g]] – bLys (mutant) + peptidoglycan analog<br />
-[[5khz]], [[5vnq]], [[6ph0]], [[6ph1]], [[6u0b]], [[6u0c]], [[6u0e]], [[6u0f]], [[6v51]], [[7m5i]] – EcLys – E. coli phage<br />
-[[5ki1]], [[5ki2]], [[5ki3]], [[5ki8]], [[5kig]], [[5kii]], [[5kim]], [[5kio]], [[5xpe]], [[6pgy]], [[6pgz]] – EcLys (mutant)<br />
-[[6akv]] – Lys – B. cereus phage<br />
-[[6fhg]] – Lys – Thermus phage<br />
-[[7kwt]], [[7kww]], [[7kwy]] – PLyCB (mutant) – Streptococcus phage<br />
-[[7aqh]] – PLyCB cell wall-binding domain<br />
-[[6yj1]] – PLyCB peptidase domain<br />
-[[4jz5]] – Ply40 catalytic domain – Listeria phage<br />
-[[4krt]] – Lys – Clostridium phage<br />
-[[2mk5]] – GH15Lys residues 368-495 – phage GH15 – NMR<br />
-[[4olk]] – GH15Lys CHAP domain residues 1-165<br />
-[[4ols]] – GH15Lys amidase domain residues 165-403<br />
 </StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]