Laminin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (5 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='5xau' size='340' side='right' caption='Human | <StructureSection load='5xau' size='340' side='right' caption='Human laminin integrin binding domain. Subunit α-5 (grey, yellow), subunit β-1 (green, light pink), subunit γ-1 (yellow, cyan) and Ca+2 (green) (PDB code [[5xau]])' scene='84/842000/Cv/1'> | ||
== Function == | == Function == | ||
| Line 13: | Line 13: | ||
== Structural highlights == | == Structural highlights == | ||
The interaction os laminin with integrin β1 metlion-dependent adhesion site is via the LAM γ chain tail. The critical LAM residue for binding integrin is a Glu residue in chain γ-1<ref>PMID:28879238</ref>. | |||
</StructureSection> | </StructureSection> | ||
| Line 20: | Line 20: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[4yeq]], [[4yep]] - hLAM subunit α-2 L4b domain 1177-1379 | [[8dmk]] - hLAM subunit α-1+beta-1+gamma-1 – human – Cryo EM<br /> | ||
[[5xau]] - hLAM integrin-binding domain subunit α-5 | [[4yeq]], [[4yep]] - hLAM subunit α-2 L4b domain 1177-1379 <br /> | ||
[[5xau]] - hLAM integrin-binding domain subunit α-5 2655-3327 + hLAM subunit β-1 1714-1786 + hLAM subunit γ-1 1528-1609 (mutant)<br /> | |||
[[7cec]] - hLAM integrin-binding domain subunit α-5 2655-3327 (mutant) + hLAM subunit β-1 1714-1786 + hLAM subunit γ-1 1528-1609 + integrin α6β1– Cryo EM<br /> | |||
[[5lf2]] - rLAM subunit β-2 LE5-LF-LE6 domain 523-833 - rat<br /> | [[5lf2]] - rLAM subunit β-2 LE5-LF-LE6 domain 523-833 - rat<br /> | ||
[[2jd4]] - mLAM subunit α-1 LG4-5 domain 2706-3084 (mutant) - mouse<br /> | [[2jd4]] - mLAM subunit α-1 LG4-5 domain 2706-3084 (mutant) - mouse<br /> | ||
| Line 34: | Line 36: | ||
[[1klo]] - mLAM subunit γ-1 module III 3-5 771-932<br /> | [[1klo]] - mLAM subunit γ-1 module III 3-5 771-932<br /> | ||
[[1npe]] - mLAM subunit γ-1 module III 3-5 + nidogen G3 YWTD domain<br /> | [[1npe]] - mLAM subunit γ-1 module III 3-5 + nidogen G3 YWTD domain<br /> | ||
[[5mc9]] - mLAM integrin-binding domain subunit α-1 2079-2707 + mLAM subunit β-1 1735-1786 + mLAM subunit γ-1 1548- | [[5mc9]] - mLAM integrin-binding domain subunit α-1 2079-2707 + mLAM subunit β-1 1735-1786 + mLAM subunit γ-1 1548-1607<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||