Lactose Permease: Difference between revisions
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[[Image:Lacpermmodel.jpg|thumb|left|Physical Model of Lactose Permease based on [[1pv7]] from the [http://cbm.msoe.edu/ MSOE Center for BioMolecular Modeling] ]] | [[Image:Lacpermmodel.jpg|thumb|left|Physical Model of Lactose Permease based on [[1pv7]] from the [http://cbm.msoe.edu/ MSOE Center for BioMolecular Modeling] ]] | ||
===Function of Lactose Permease=== | ===Function of Lactose Permease=== | ||
[[Lactose Permease]] (PDB entry [[1pv7]]) is a transmembrane protein that facilitates the passage of lactose across the phospholipid bi-layer of the cell membrane. The transport mechanism used is an active co-transport that uses the inwardly directed H+ electrochemical gradient as its driving force. As a result, the lactose is accompanied from the periplasm to the cytoplasm of the cell by an H+ proton<ref>PMID:15950162</ref>. '''Fucose permease''' transports fucose across cell membrane. | [[Lactose Permease]] or '''galactoside permease''' (PDB entry [[1pv7]]) is a transmembrane protein that facilitates the passage of lactose across the phospholipid bi-layer of the cell membrane. The transport mechanism used is an active co-transport that uses the inwardly directed H+ electrochemical gradient as its driving force. As a result, the lactose is accompanied from the periplasm to the cytoplasm of the cell by an H+ proton<ref>PMID:15950162</ref>. '''Fucose permease''' transports fucose across cell membrane. | ||
Lactose is a disaccharide carbohydrate found primarily in mammalian milk. The disaccharide consists of the monosacharides glucose and galactose. When the lactose is ingested and absorbed into the cell, the enzyme lactase breaks the disaccharide into its monosaccharide subunits. These are in turn used in the cellular respiration process and broken down further into energy for the cell. | Lactose is a disaccharide carbohydrate found primarily in mammalian milk. The disaccharide consists of the monosacharides glucose and galactose. When the lactose is ingested and absorbed into the cell, the enzyme lactase breaks the disaccharide into its monosaccharide subunits. These are in turn used in the cellular respiration process and broken down further into energy for the cell. | ||
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**[[2cfp]], [[2cfq]], [[1pv6]] - EcLACY (mutant) <br /> | **[[2cfp]], [[2cfq]], [[1pv6]] - EcLACY (mutant) <br /> | ||
**[[2y5y]] – EcLACY (mutant) + affinity activator<br /> | **[[2y5y]] – EcLACY (mutant) + affinity activator<br /> | ||
**[[1pv7]] - EcLACY (mutant) + | **[[4oaa]] - EcLACY (mutant) + galactose<br /> | ||
**[[1pv7]], [[4zyr]] - EcLACY (mutant) + galactoside<br /> | |||
**[[5gxb]], [[6c9w]] – EcLACY + nanobody<br /> | |||
**[[6vbg]] – EcLACY (mutant) + nanobody + galactoside derivative<br /> | |||
*Fucose permease | *Fucose permease | ||