5cqs: Difference between revisions

<StructureSection load='5cqs' size='340' side='right'caption='[[5cqs]], [[Resolution|resolution]] 2.70&Aring;' scene=''>

<table><tr><td colspan='2'>[[5cqs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CQS FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqs OCA], [https://pdbe.org/5cqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cqs RCSB], [https://www.ebi.ac.uk/pdbsum/5cqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cqs ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ELP1_YEAST ELP1_YEAST] Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. Independently, ELP3 may be involved in polarized exocytosis. It is required for the polarized localization of GTPase-activating protein SEC2. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.<ref>PMID:10024884</ref> <ref>PMID:11296232</ref> <ref>PMID:11689709</ref> <ref>PMID:11904415</ref> <ref>PMID:12424236</ref> <ref>PMID:13680368</ref> <ref>PMID:15769872</ref> <ref>PMID:15780940</ref>  

[[Category: Large Structures]]

[[Category: Saccharomyces cerevisiae S288C]]

[[Category: Diao W]]

[[Category: Li F]]

[[Category: Lin Z]]

[[Category: Long J]]

[[Category: Shen Y]]

[[Category: Xu H]]