Liraglutide: Difference between revisions
New page: <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene=''> Liraglutide, sold under the brand name Victoza among others, is an anti-diabetic medication... |
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<StructureSection load='' size='340' side='right' caption=' | <StructureSection load='4apd' size='340' side='right' caption='NMR structure of liraglutide. PDB entry [[4apd]]' scene='96/969657/Cv/1'> | ||
Liraglutide, sold under the brand name Victoza among others, is an anti-diabetic medication used to treat type 2 diabetes, and chronic obesity. See also [https://en.wikipedia.org/wiki/Liraglutide]. | Liraglutide, sold under the brand name Victoza among others, is an anti-diabetic medication used to treat type 2 diabetes, and chronic obesity. See also [https://en.wikipedia.org/wiki/Liraglutide]. | ||
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) agonist, derived from human GLP-1-(7-37), a less common form of endogenous GLP-1. See [[Glucagon-like peptide 1 receptor|Glucagon-like peptide-1 and its receptor]] and [[Glucagon]]. | |||
It reduces meal-related hyperglycemia (for 24 hours after administration) by increasing insulin secretion (only) when required by increasing glucose levels, delaying gastric emptying, and suppressing prandial glucagon secretion. | |||
Liraglutide leads to insulin release in pancreatic beta cells in the presence of elevated blood glucose. This insulin secretion subsides as glucose concentrations decrease and approach euglycemia (normal blood glucose level). It also decreases glucagon secretion in a glucose-dependent manner and delays gastric emptying. Unlike endogenous GLP-1, liraglutide is stable against metabolic degradation by peptidases, with a plasma half-life of 13 hours. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||