6if9: Difference between revisions

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-'''Unreleased structure'''
-The entry 6if9 is ON HOLD
+==Solution-state NMR structure of G57W human gammaS crystallin==
+<StructureSection load='6if9' size='340' side='right'caption='[[6if9]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6if9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IF9 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6if9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6if9 OCA], [https://pdbe.org/6if9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6if9 RCSB], [https://www.ebi.ac.uk/pdbsum/6if9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6if9 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CRYGS_HUMAN CRYGS_HUMAN] Early-onset lamellar cataract;Early-onset sutural cataract. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/CRYGS_HUMAN CRYGS_HUMAN] Crystallins are the dominant structural components of the vertebrate eye lens.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A recently identified mutant of human gammaS-crystallin, G57W is associated with dominant congenital cataracts, the familial determinate of childhood blindness worldwide. To investigate the structural and functional changes that mediate the effect of this cataract-related mutant to compromise eye lens transparency and cause lens opacification in children, we recently reported complete sequence-specific resonance assignments of gammaS-G57W using a suite of heteronuclear NMR experiments. As a follow up, we have determined the 3D structure of gammaS-G57W and studied its conformational dynamics by solution NMR spectroscopy. Our structural dynamics results reveal greater flexibility of the N-terminal domain, which undergoes site-specific structural changes to accommodate W57, than its C-terminal counterpart. Our structural inferences that the unusual solvent exposure of W57 is associated with rearrangement of the N-terminal domain suggest an efficient pathway for increased aggregation in gammaS-G57W and illuminates the molecular dynamics underlying cataractogenic aggregation of lens crystallins in particular and aggregation of proteins in general.
-Authors: Sharma, S., Bari, K.J., Chary, K.V.R.
+Structure of G57W mutant of human gammaS-crystallin and its involvement in cataract formation.,Bari KJ, Sharma S, Chary KVR J Struct Biol. 2019 Mar 1;205(3):72-78. doi: 10.1016/j.jsb.2019.02.003. Epub 2019, Feb 12. PMID:30769148<ref>PMID:30769148</ref>
-Description: Solution-state NMR structure of G57W human gammaS crystallin
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Sharma, S]]
+<div class="pdbe-citations 6if9" style="background-color:#fffaf0;"></div>
-[[Category: Bari, K.J]]
-[[Category: Chary, K.V.R]]
+==See Also==
+*[[Crystallin 3D structures|Crystallin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bari KJ]]
+[[Category: Chary KVR]]
+[[Category: Sharma S]]