6e8w: Difference between revisions
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==MPER-TM Domain of HIV-1 envelope glycoprotein (Env)== | ==MPER-TM Domain of HIV-1 envelope glycoprotein (Env)== | ||
<StructureSection load='6e8w' size='340' side='right'caption='[[6e8w | <StructureSection load='6e8w' size='340' side='right'caption='[[6e8w]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6e8w]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6e8w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E8W FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8w OCA], [https://pdbe.org/6e8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e8w RCSB], [https://www.ebi.ac.uk/pdbsum/6e8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8w ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q74849_9HIV1 Q74849_9HIV1] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus 1]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cai | [[Category: Cai Y]] | ||
[[Category: Chen | [[Category: Chen B]] | ||
[[Category: Chou | [[Category: Chou JJ]] | ||
[[Category: Fu | [[Category: Fu Q]] | ||
[[Category: Ghantous | [[Category: Ghantous F]] | ||
[[Category: Harrison | [[Category: Harrison SC]] | ||
[[Category: Liu | [[Category: Liu Z]] | ||
[[Category: Peng | [[Category: Peng H]] | ||
[[Category: Piai | [[Category: Piai A]] | ||
[[Category: Rits-Volloch | [[Category: Rits-Volloch S]] | ||
[[Category: Seaman | [[Category: Seaman MS]] | ||
[[Category: Shaik | [[Category: Shaik MM]] | ||
Latest revision as of 13:43, 14 June 2023
MPER-TM Domain of HIV-1 envelope glycoprotein (Env)MPER-TM Domain of HIV-1 envelope glycoprotein (Env)
Structural highlights
FunctionPublication Abstract from PubMedThe membrane-proximal external region (MPER) of the HIV-1 envelope glycoprotein (Env) bears epitopes of broadly neutralizing antibodies (bnAbs) from infected individuals; it is thus a potential vaccine target. We report an NMR structure of the MPER and its adjacent transmembrane domain in bicelles that mimic a lipid-bilayer membrane. The MPER lies largely outside the lipid bilayer. It folds into a threefold cluster, stabilized mainly by conserved hydrophobic residues and potentially by interaction with phospholipid headgroups. Antigenic analysis and comparison with published images from electron cryotomography of HIV-1 Env on the virion surface suggest that the structure may represent a prefusion conformation of the MPER, distinct from the fusion-intermediate state targeted by several well-studied bnAbs. Very slow bnAb binding indicates that infrequent fluctuations of the MPER structure give these antibodies occasional access to alternative conformations of MPER epitopes. Mutations in the MPER not only impede membrane fusion but also influence presentation of bnAb epitopes in other regions. These results suggest strategies for developing MPER-based vaccine candidates. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein.,Fu Q, Shaik MM, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC, Seaman MS, Chen B, Chou JJ Proc Natl Acad Sci U S A. 2018 Sep 5. pii: 1807259115. doi:, 10.1073/pnas.1807259115. PMID:30185554[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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