Acetylcholine: Difference between revisions
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<applet load='Ach1.pdb' size='400' frame='true' align='right' | <applet load='Ach1.pdb' size='400' frame='true' align='right' | ||
scene='Acetylcholine/Cv/1' /> | scene='Acetylcholine/Cv/1' /> | ||
Acetylcholine is a [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter], which means it acts as a chemical messenger in the nervous system. It plays a vital role in transmitting signals between nerve cells and regulating various physiological processes in the body. Acetylcholine is synthesized from choline and acetyl coenzyme A by the enzyme choline acetyltransferase. | |||
In the central nervous system, acetylcholine is involved in cognitive functions such as attention, learning, and memory. It helps to regulate the sleep-wake cycle and plays a role in arousal and alertness. Acetylcholine is also crucial for motor control, as it transmits signals from motor neurons to muscles, enabling muscle contraction. | |||
In the peripheral nervous system, acetylcholine functions in the autonomic nervous system. It is released by parasympathetic neurons and serves as the primary neurotransmitter in the parasympathetic division, which controls rest and digest functions. Acetylcholine regulates heart rate, digestion, and other involuntary processes. | |||
Dysfunction or imbalances in acetylcholine are associated with various neurological disorders. For instance, a deficiency of acetylcholine is observed in Alzheimer's disease, which leads to memory impairment and cognitive decline. Myasthenia gravis is another condition where acetylcholine receptors at the neuromuscular junction are targeted by the immune system, causing muscle weakness and fatigue. | |||
[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] ([http://www.expasy.org/enzyme/3.1.1.7 EC 3.1.1.7], ''e.g.'' from [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''], ''Tc''AChE) [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Cv/2'>(ACh)</scene>, producing <scene name='2ace/Cv/3'>choline and an acetate</scene> group. ACh directly binds <scene name='2ace/Cv/4'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Cv/5'>catalytic triad (Ser200, His440, and Glu327)</scene> of (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Cv/6'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition. After this binding acetylcholinesterase <scene name='2ace/Cv/7'>hydrolysizes</scene> ACh. | [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] ([http://www.expasy.org/enzyme/3.1.1.7 EC 3.1.1.7], ''e.g.'' from [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''], ''Tc''AChE) [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Cv/2'>(ACh)</scene>, producing <scene name='2ace/Cv/3'>choline and an acetate</scene> group. ACh directly binds <scene name='2ace/Cv/4'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Cv/5'>catalytic triad (Ser200, His440, and Glu327)</scene> of (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Cv/6'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition. After this binding acetylcholinesterase <scene name='2ace/Cv/7'>hydrolysizes</scene> ACh. | ||
In summary, acetylcholine is a crucial neurotransmitter involved in cognitive, motor, and autonomic functions. Its role in the nervous system is diverse and essential for maintaining proper communication between nerve cells and regulating various physiological processes throughout the body. | |||
===Additional Resources=== | ===Additional Resources=== | ||
For additional information, see: [[Alzheimer's Disease]] | For additional information, see: [[Alzheimer's Disease]] | ||
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Latest revision as of 09:37, 11 June 2023
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Acetylcholine is a neurotransmitter, which means it acts as a chemical messenger in the nervous system. It plays a vital role in transmitting signals between nerve cells and regulating various physiological processes in the body. Acetylcholine is synthesized from choline and acetyl coenzyme A by the enzyme choline acetyltransferase.
In the central nervous system, acetylcholine is involved in cognitive functions such as attention, learning, and memory. It helps to regulate the sleep-wake cycle and plays a role in arousal and alertness. Acetylcholine is also crucial for motor control, as it transmits signals from motor neurons to muscles, enabling muscle contraction.
In the peripheral nervous system, acetylcholine functions in the autonomic nervous system. It is released by parasympathetic neurons and serves as the primary neurotransmitter in the parasympathetic division, which controls rest and digest functions. Acetylcholine regulates heart rate, digestion, and other involuntary processes.
Dysfunction or imbalances in acetylcholine are associated with various neurological disorders. For instance, a deficiency of acetylcholine is observed in Alzheimer's disease, which leads to memory impairment and cognitive decline. Myasthenia gravis is another condition where acetylcholine receptors at the neuromuscular junction are targeted by the immune system, causing muscle weakness and fatigue.
Acetylcholinesterase (EC 3.1.1.7, e.g. from Torpedo californica, TcAChE) hydrolysizes the neurotransmitter acetylcholine , producing group. ACh directly binds (via its nucleophilic Oγ atom) within the catalytic triad of (ACh/TcAChE structure 2ace). The residues are also important in the ligand recognition. After this binding acetylcholinesterase ACh.
In summary, acetylcholine is a crucial neurotransmitter involved in cognitive, motor, and autonomic functions. Its role in the nervous system is diverse and essential for maintaining proper communication between nerve cells and regulating various physiological processes throughout the body.
Additional ResourcesAdditional Resources
For additional information, see: Alzheimer's Disease