Interferon regulatory factor: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
 <StructureSection load='1if1' size='400' side='right' caption='Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry [[1if1]])' scene=''>
+== Function ==
+'''Interferon regulatory factor''' (IRF) regulate transcription of interferons<ref>PMID:17399883</ref>.<br />
+*  '''IRF-1''' functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter<ref>PMID:15226432</ref>.<br />
+*  '''IRF-3''' and '''IRF-7''' are activated by viruses or after binding to Toll-like receptors<ref>PMID:9488451</ref>.<br />
+*  '''IRF-4''' is lymphoid-specific and functions in the development of immune cells<ref>PMID:23980171</ref>.
+*  '''IRF-9''' is a conductor of the cellular responses to interferons<ref>PMID:26987614</ref>.
+See also [[Interferon]]
+== Relevance ==
+Inhibition of IRF-5 may treat autoimmune diseases.  Increased level of IRF-5 may help weak immune systems<ref>PMID:11846976</ref>.  IRF-9 has a critical role in cerebral ischemic stroke<ref>PMID:25186738</ref>.
-'''Interferon regulatory factor''' (IRF) regulate transcription of interferons.  IRF-1 functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter.  IRF-3 and IRF-7 are activated by viruses or after binding to Toll-like receptors.  IRF-4 is lymphoid-specific and functions in the development of immune cells.
+== Disease ==
+Deficiency in IRF-2 compromises development of natural killer cells and T helper cells<ref>PMID:10934221</ref>.
+</StructureSection>
 ==3D structures of interferon regulatory factor==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-===Interferon regulatory factor 1===
+*Interferon regulatory factor 1
-[[1if1]] - mIRF DNA binding domain + DNA – mouse
+**[[1if1]] - mIRF DNA binding domain + DNA – mouse
-===Interferon regulatory factor 2===
+*Interferon regulatory factor 2
-[[1irf]], [[1irg]] – mIRF DNA binding domain – NMR<BR />
+**[[1irf]], [[1irg]] – mIRF DNA binding domain – NMR<BR />
-[[2irf]] - mIRF DNA binding domain + DNA
+**[[2irf]] - mIRF DNA binding domain + DNA
-===Interferon regulatory factor 3===
+*Interferon regulatory factor 3
-[[1qwt]], [[1j2f]] – mIRF<BR />
+**[[1qwt]], [[1j2f]] – mIRF<BR />
-[[3a77]]  – hIRF DNA binding domain<BR />
+**[[3a77]]  – hIRF DNA binding domain<BR />
-[[3qu6]] - hIRF DNA binding domain (mutant) <BR />
+**[[3qu6]] - hIRF DNA binding domain (mutant) <BR />
-[[1t2k]] - hIRF DNA binding domain + interferon B enhancer + transcription factor AP-1 + DNA – human<BR />
+**[[1t2k]] - hIRF DNA binding domain + interferon B enhancer + transcription factor AP-1 + DNA – human<BR />
-[[2o6g]] - hIRF DNA binding domain + interferon B enhancer<BR />
+**[[2o6g]] - hIRF DNA binding domain + interferon B enhancer<BR />
-[[2pi0]] - hIRF DNA binding domain + interferon B promoter<BR />
+**[[2pi0]] - hIRF DNA binding domain + interferon B promoter<BR />
-[[1zoq]] – hIRF + CREB-binding protein<BR />
+**[[1zoq]] – hIRF + CREB-binding protein<BR />
-[[2o61]] – hIRF3/IRF7/transcription factor + nuclear factor + DNA
+**[[2o61]] – hIRF3/IRF7/transcription factor + nuclear factor + DNA<br />
+**[[5jej]] – hIRF + stimulator of interferon genes protein<br />
+**[[5jek]], [[5jel]], [[5jeo]], [[5jer]] – hIRF + peptide<br />
+**[[5jem]] – hIRF + CBP<br />
+**[[7jfl]], [[7jfm]] – mIRF + CBP<br />
-===Interferon regulatory factor 4===
+*Interferon regulatory factor 4
-[[2dll]] – hIRF IRF domain - NMR<BR />
+**[[2dll]] – hIRF IRF domain 8-115 - NMR<BR />
+**[[6td4]] – hIRF DBD 20-139 (mutant)<br />
+**[[7jm4]], [[7o56]], [[7ogs]], [[7oot]] – hIRF DBD + DNA<br />
+**[[5bvi]] – mIRF IAD domain<br />
-===Interferon regulatory factor 5===
+*Interferon regulatory factor 5
-[[3dsh]] – hIRF IRF domain (mutant)
+**[[3dsh]] – hIRF IRF domain (mutant)
-===Interferon regulatory factor 7===
+*Interferon regulatory factor 7
-[[3qu3]] - mIRF DNA binding domain
+**[[3qu3]] - mIRF DNA binding domain
+*Interferon regulatory factor 9
+**[[5oem]] – mIRF IAD domain<br />
+**[[5oen]] – mIRF IAD domain + STAT2<br />
+*Lytic viral interferon regulatory factor
+**[[4hlx]] – hvIRF DNA-binding domain - herpesvirus<br />
+**[[4hly]] – hvIRF DNA-binding domain + DNA<br />
+}}
+== References ==
+<references/>
-</StructureSection>
+[[Category: Topic Page]]