8iw4: Difference between revisions

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New page: '''Unreleased structure''' The entry 8iw4 is ON HOLD Authors: Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K. Description: Cryo-EM structure of the ...
 
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'''Unreleased structure'''


The entry 8iw4 is ON HOLD
==Cryo-EM structure of the SPE-bound mTAAR9-Gs complex==
 
<StructureSection load='8iw4' size='340' side='right'caption='[[8iw4]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
Authors: Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8iw4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IW4 FirstGlance]. <br>
Description: Cryo-EM structure of the SPE-bound mTAAR9-Gs complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iw4 OCA], [https://pdbe.org/8iw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iw4 RCSB], [https://www.ebi.ac.uk/pdbsum/8iw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iw4 ProSAT]</span></td></tr>
[[Category: Sun, J.P]]
</table>
[[Category: Zhang, M.H]]
== Function ==
[[Category: Lian, S]]
[https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
[[Category: Guo, L.L]]
== References ==
[[Category: Xu, Y.F]]
<references/>
[[Category: Li, Q]]
__TOC__
[[Category: Yang, F]]
</StructureSection>
[[Category: Rong, N.K]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Guo LL]]
[[Category: Li Q]]
[[Category: Lian S]]
[[Category: Rong NK]]
[[Category: Sun JP]]
[[Category: Xu YF]]
[[Category: Yang F]]
[[Category: Zhang MH]]

Latest revision as of 08:46, 31 May 2023

Cryo-EM structure of the SPE-bound mTAAR9-Gs complexCryo-EM structure of the SPE-bound mTAAR9-Gs complex

Structural highlights

8iw4 is a 5 chain structure with sequence from Homo sapiens, Mus musculus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBB1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.[1]

References

  1. Johnston CA, Kimple AJ, Giguere PM, Siderovski DP. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Structure. 2008 Jul;16(7):1086-94. PMID:18611381 doi:http://dx.doi.org/10.1016/j.str.2008.04.010

8iw4, resolution 3.49Å

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OCA