Insulin 3D Structures: Difference between revisions

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(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}})  
(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}})  
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
* Insulin
* Insulin


** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]], [[2mli]], [[4p65]], [[4rxw]], [[2w44]], [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4xc4]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[5cny]], [[5bts]], [[5bqq]], [[5bpo]], [[5boq]] - hIns A chain + B chain – human <BR />
**[[5bts]], [[4ak0]], [[2lgb]], [[1guj]], [[2c8r]], [[2c8q]], [[3i40]], [[3i3z]], [[5en9]], [[3zi3]], [[6s34]], [[6h3m]], [[6o17]], [[6s34]], [[7ac4]], [[7jp3]], [[7qgf]], [[7s4y]], [[7z5l]], [[7z5q]], [[8gsg]] - hIns A chain + B chain – human<br />
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR />
**[[6jr3]] - hIns A chain + B chain – Cryo EM<br />
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[5hrq]], [[5hqi]], [[5hpu]], [[5hpr]], [[5ena]], [[5en9]], [[6ck2]], [[5uu4]], [[5uu3]], [[5uu2]], [[5usv]], [[5uss]], [[5usp]], [[5uru]], [[5urt]], [[5uqa]], [[5uoz]], [[1w8p]], [[4cxl]], [[4cxn]], [[4cy7]], [[4nib]], [[4une]], [[4ung]], [[4unh]], [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]],[[ 2ws7]], [[1qj0]], [[3p2x]] – hIns A chain + B chain (mutant) <BR />  
**[[3e7y]], [[3e7z]], [[2qiu]], [[1os3]], [[1os4]], [[1mso]], [[1g7a]], [[1g7b]], [[1trz]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[2vjz]], [[2vk0]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[6gv0]], [[6zi8]] - hIns A chain + B chain + Zn<br />
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
**[[1fu2]], [[1fub]] - hIns A chain + B chain + Zn – powder diffraction<br />
** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]], [[5t7r]], [[1zeh]], [[3zi3]], [[5azz]] - hIns A chain (mutant) + B chain <BR />
**[[5t7r]] - hIns A chain (mutant) + B chain<br />
**[[5mwq]] - hIns A chain (mutant) + B chain (mutant)<br />
**[[1b9e]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]], [[5ena]], [[2ws4]], [[7nhu]] - hIns A chain + B chain (mutant)<br />
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]], [[3rto]], [[3fhp]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<BR />
**[[3bxq]], [[1qj0]], [[6tyh]] – hIns A chain + B chain (mutant) + Zn<br />
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR />
**[[3ir0]], [[3inc]], [[3ilg]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]], [[4rxw]], [[4fka]], [[6p4z]] - hIns A chain + B chain + non-Zn metal ion<br />
** [[3rto]], [[3fhp]] - pIns A chain + B chain <br />  
**[[1jca]], [[1j73]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br />
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
**[[5mwq]], [[5azz]], [[6s4i]], [[6s4j]], [[6vet]] - hIns A chain (mutant) + B chain (mutant)<br />
** [[6ins]] – pIns single chain<br />
**[[6p4z]] - hIns A chain + B chain + Co + Gd<br />
** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]], [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain + B chain – bovine <BR />
**[[2g4m]], [[9ins]], [[3t2a]], [[4a7e]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<br />
**[[5jyq]] - Ins A chain + B chain – ''Conus geographus''<br />
**[[1iza]] - pIns A chain + B chain (mutant)<br />
**[[1zni]], [[4ins]], [[3ins]], [[3rto]], [[3fhp]] - pIns A chain + B chain + Zn<br />
**[[1izb]] - pIns A chain + B chain (mutant) + Zn<br />
**[[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<br />
**[[1m5a]] - pIns A chain + B chain + Co<br />
**[[6ins]] – pIns single chain<br />
**[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[2bn1]], [[2bn3]], [[6or0]], [[6qq7]], [[6qqg]], [[6qrh]], [[6qrk]] - bIns A chain + B chain – bovine<br />
**[[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[2a3g]], - bIns A chain + B chain + Zn <br />
**[[6zhb]] - bIns A chain + B chain + Zn – electron diffraction<br />
**[[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain + non-Zn metal ion<br />
**[[6q8q]] - bIns A chain + B chain + Ar <br />
 
*Insulin structures using NMR
 
**[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1xgl]], [[2mvc]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2hiu]], [[2jv1]], [[6x4x]] - hIns A chain + B chain – NMR<br />
**[[1ai0]], [[1aiy]] - hIns A chain + B chain + Zn – NMR<br />
**[[1t1k]], [[1t1p]], [[1t1q]], [[2mpg]], [[2mpi]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<br />
**[[2jmn]], [[2h67]], [[2hho]], [[1jco]], [[1a7f]], [[2mvd]], [[2kjj]], [[2k91]], [[2rn5]], [[1hiq]], [[1hit]]  - hIns A chain + B chain (mutant) – NMR<br />
**[[2jum]], [[2juv]], [[1k3m]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]], [[1lkq]], [[2m1d]] - hIns A chain (mutant) + B chain (mutant) – NMR<br />
**[[2kqq]], [[2l1y]] - hIns A chain (mutant) + B chain + Ala – NMR<br />
**[[2kjr]] - hIns A chain + B chain (mutant) + Ala – NMR<br />
**[[7elj]] - bIns A chain + B chain + tetrapeptide – NMR<br />
**[[2hh4]] - hIns A chain + B chain (mutant) + Ser – NMR<br />
**[[2kju]] - hIns A chain + B chain (mutant) + Glu – NMR<br />
**[[2juu]] - hIns A chain (mutant) + B chain (mutant) + Thr – NMR<br />
**[[1kmf]] - hIns A chain (mutant) + B chain (mutant) + Ile – NMR<br />
**[[1bzv]] - hIns A chain (mutant) + B chain (mutant) + Ala – NMR<br />
**[[2lwz]], [[5wbt]] – hIns single chain - NMR<br />
**[[2jzq]] – hIns single chain (mutant) - NMR<br />
**[[1ho0]] - bIns B chain (mutant) – NMR<br />
**[[5miz]], [[6kh8]], [[6kh9]], [[6kha]] - bIns A chain + B chain – NMR<br />


* Insulin structures using NMR
*Insulin complexes


** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]], [[2mpg]], [[2mvc]] - hIns A chain + B chain – NMR<BR />
**[[4xc4]] - hIns A chain + B chain + sulfatide + Zn<br />
** [[2hiu]] – apo-hIns A chain + B chain – NMR<BR />
**[[1ben]] - hIns A chain + B chain + hydroxybenzamide + Zn<br />
** [[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]], [[2mpi]], [[2l1y]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<BR />
**[[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide + Zn<br />
** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]], [[2mvd]], [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain + B chain (mutant) – NMR<BR />
**[[5boq]] - hIns A chain + B chain + norleucine<br />
** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]], [[1lkq]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR />
**[[5bpo]] - hIns A chain + B chain + norvaline<br />
** [[2jv1]] – apo-hIns A chain + B chain (mutant) – NMR<BR />
**[[5bqq]] - hIns A chain + B chain + norvaline + Zn<br />
** [[2jzq]] - hIns A chain – NMR<BR />
**[[2mli]] - hIns A chain + B chain + Phe derivative<br />
** [[1ho0]] - hIns B chain (mutant) – NMR<BR />
**[[2ws1]] - hIns A chain + B chain + Tyr derivative<br />
** [[2lwz]], [[5bwt]] – hIns single chain - NMR<br />
**[[5hqi]], [[5hpr]], [[4cxl]], [[2wrw]] - hIns A chain + B chain (mutant) + Pro derivative<br />
**[[5miz]] - bIns A chain + B chain – NMR
**[[4nib]] - hIns A chain (mutant) + B chain + Ala <br />
**[[3fq9]] - hIns A chain (mutant) + B chain + Ala + Zn<br />
**[[4cxn]], [[4cy7]], [[2wru]], [[2wrx]], [[2ws0]] - hIns A chain + B chain (mutant) + Ala derivative<br />
**[[2wrv]] - hIns A chain + B chain (mutant) + His derivative<br />
**[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol + Zn<br />
**[[2omg]] - hIns A chain + B chain + urea + cresol + Zn<br />
**[[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate + resorcinol + Zn<br />
**[[4akj]], [[4ajz]], [[3v19]], [[1znj]] - hIns A chain + B chain + phenol + Zn<br />
**[[3kq6]], [[1xw7]], [[1rwe]] - hIns A chain (mutant) + B chain + phenol + Zn<br />
**[[1w8p]], [[2ws7]], [[1qiy]] - hIns A chain + B chain (mutant) + phenol + Zn<br />
**[[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol + Zn<br />
**[[3v1g]] - hIns A chain + B chain + phenol + Glu + Zn<br />
**[[1q4v]] - hIns A chain + B chain + phenol + Ile + Zn<br />
**[[3rov]], [[3p2x]] - hIns A chain + B chain (mutant) + phenol + Ala + Zn<br />
**[[5hpu]], [[5uu4]], [[5uu3]], [[5uu2]], [[5usv]], [[5uss]], [[5usp]], [[5uru]], [[5urt]], [[5uqa]], [[5uoz]] - hIns A chain + B chain + phenol + Pro derivative + Zn<br />
**[[5hrq]] - hIns A chain + B chain (mutant) + phenol + Pro derivative + Zn<br />
**[[3zs2]], [[3zqr]] - hIns A chain + B chain + phenol + Phe derivative + Zn<br />
**[[2ws6]] - hIns A chain + B chain + phenol + Tyr derivative + Zn<br />
**[[1xda]] - hIns A chain + B chain + phenol + myristic acid + Zn<br />
**[[6ck2]] - hIns A chain + B chain (mutant) + phenol + ornithine + Zn<br />
**[[1qiz]] - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn<br />
**[[1ev3]], [[1ev6]], [[1uz9]], [[4gbn]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[6gnq]] - hIns A chain + B chain + cresol + Zn<br />
**[[1zeh]] - hIns A chain (mutant) + B chain (mutant) + cresol + Zn<br />
**[[1evr]], [[4ajx]], [[3zu1]] - hIns A chain + B chain + resorcinol + Zn<br />
**[[5mam]] - hIns A chain + B chain + serotonin + Zn<br />
**[[5mt9]], [[5mt3]] - hIns A chain + B chain + serotonin + arginine + Zn<br />
**[[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<br />
**[[1mpj]], [[3gky]], [[1wav]] - pIns A chain + B chain + phenol + Zn<br />
**[[2tci]] - pIns A chain + B chain + thiocyanate + Zn<br />
**[[3mth]] - pIns A chain + B chain + methylparaben + Zn<br />
**[[7ins]] - pIns A chain + B chain + clupeine + cresol + Zn<br />
**[[5jyq]] - CgIns A chain + B chain + Pro derivative – ''Conus geographus''<br />


* Insulin complexes
*Insulin complexes with protein


** [[4xc4]] - hIns A chain + B chain + sulfatide<BR />
**[[3q6e]] - hIns A chain + B chain + synthetic receptor<br />
** [[1ben]] - hIns A chain + B chain + hydroxybenzamide<BR />
**[[7bw7]], [[7bw8]], [[7bwa]], [[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7qid]], [[7sth]], [[7sti]], [[7stj]], [[7stk, [[8guy]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
** [[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide<BR />
**[[7l7j]], [[7sl1]], [[7sl2]], [[7sl3]] - hIns A chain (mutant) + B chain + insulin receptor – Cryo EM<br />
** [[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol<BR />
**[[7sl4]], [[7sl6]] - hIns A chain + B chain (mutant) + insulin receptor – Cryo EM<br />
** [[2omg]] - hIns A chain + B chain + urea + cresol<br />
**[[7mqs]] - hIns A chain (mutant) + B chain (mutant) + insulin receptor – Cryo EM<br />
** [[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate<BR />
**[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] - hIns A chain + B chain + insulin receptor + DNA – Cryo EM<br />
** [[1jk8]] - hIns B chain peptide + HLA<BR />
**[[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme + Zn<br />
** [[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol<br />
**[[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme<br />
** [[1qiy]] - hIns A chain + B chain (mutant) + phenol<br />
**[[6b3q]], [[6bfc]] - hIns A chain + B chain + insulin-degrading enzyme – Cryo EM<br />
** [[1qiz]] - hIns A chain + B chain (mutant) + resorcinol<BR />
**[[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn<br />
** [[1ev3]], [[1ev6]] - hIns A chain + B chain+ cresol<br />
**[[3w11]], [[5kqv]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
** [[1evr]] - hIns A chain + B chain + resorcinol<BR />
**[[6b70]] - hIns A chain + B chain + insulin-degrading enzyme + antibody – Cryo EM<br />
** [[3q6e]] - hIns A chain + B chain + synthetic receptor<BR />
**[[6jk8]], [[7v3p]] - hIns A chain + B chain + IGF-1R – Cryo EM<br />
** [[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme<br />
**[[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn<br />
** [[2wby]], [[2wc0]], [[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme (mutant)<br />
**[[4oga]], [[6vep]] - hIns A chain + B chain + insulin receptor + antibody<br />
** [[3w11]], [[5kqv]], [[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
**[[6ce7]], [[6ce9]], [[6ceb]], [[6hn5]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
**[[6ce7]], [[6ce9]], [[6ceb]] - hIns A chain + B chain + insulin receptor <br />
**[[6z7w]], [[6z7y]], [[6z7z]] - pIns A chain + B chain + antibody<br />
**[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br />
**[[6z7z]] - pIns A chain + B chain + antibody<br />
**[[5mam]] - hIns A chain + B chain + serotonin <br />
**[[7ins]] - pIns A chain + B chain + clupeine<br />
**[[5mt9]], [[5mt3]] - hIns A chain + B chain + serotonin + arginine<br />
**[[8ez0]] - mIns + insulin receptor – Cryo EM<br />
** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
**[[6veq]] - CgIns A chain + B chain + insulin receptor + antibody<br />
** [[1mpj]] - pIns A chain + B chain + phenol<br />
** [[2tci]] - pIns A chain + B chain + thiocyanate<BR />
** [[3mth]] - pIns A chain + B chain + methylparaben<BR />
** [[1zei]] - pIns A chain (mutant) + cresol<br />
** [[7ins]] - pIns A chain + B chain + clupeine + cresol<br />


* Proinsulin
* Proinsulin
Line 83: Line 140:
*Insulin lispro
*Insulin lispro


**[[5udp]] – hIns – synthetic<br />
**[[5udp]] – LishIns – synthetic<br />
**[[6nwv]] - hIns A chain + hInsLis B chain + cresol + Zn<br />


*Insulin glargine
*Insulin glargine


**[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br />
**[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br />


}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 10:56, 30 May 2023

(Updated on 30-May-2023)

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky, Michal Harel, Joel L. Sussman
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