1gq0: Difference between revisions

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-[[Image:1gq0.png|left|200px]]
-<!--
+==Solution structure of Antiamoebin I, a membrane channel-forming polypeptide; NMR, 20 structures==
-The line below this paragraph, containing "STRUCTURE_1gq0", creates the "Structure Box" on the page.
+<StructureSection load='1gq0' size='340' side='right'caption='[[1gq0]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1gq0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Emericellopsis_sp._2723 Emericellopsis sp. 2723]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GQ0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene>, <scene name='pdbligand=PRD_000161:Antiamoebin+1'>PRD_000161</scene></td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gq0 OCA], [https://pdbe.org/1gq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gq0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gq0 ProSAT]</span></td></tr>
-{{STRUCTURE_1gq0|  PDB=1gq0  |  SCENE=  }}
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Antiamoebin I is a membrane-active peptaibol produced by fungi of the species Emericellopsis which is capable of forming ion channels in membranes. Previous structure determinations by x-ray crystallography have shown the molecule is mostly helical, with a deep bend in the center of the polypeptide, and that the backbone structure is independent of the solvent used for crystallization. In this study, the solution structure of antiamoebin was determined by NMR spectroscopy in methanol, a solvent from which one of the crystal structures was determined. The ensemble of structures produced exhibit a right-handed helical C terminus and a left-handed helical conformation toward the N-terminus, in contrast to the completely right-handed helices found in the crystal structures. The NMR results also suggest that a "hinge" region exists, which gives flexibility to the polypeptide in the central region, and which could have functional implications for the membrane insertion process. A model for the membrane insertion and assembly process is proposed based on the antiamoebin solution and crystal structures, and is contrasted with the assembly and insertion mechanism proposed for other ion channel-forming polypeptides.
-===SOLUTION STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE CHANNEL-FORMING POLYPEPTIDE; NMR, 20 STRUCTURES===
+Solution NMR studies of antiamoebin, a membrane channel-forming polypeptide.,Galbraith TP, Harris R, Driscoll PC, Wallace BA Biophys J. 2003 Jan;84(1):185-94. PMID:12524274<ref>PMID:12524274</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12524274}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1gq0" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12524274 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12524274}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[1gq0]] is a 1 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Emericellopsis_sp._2723 Emericellopsis sp. 2723]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ0 OCA].
-==See Also==
-*[[Ion channels]]
-==Reference==
-<ref group="xtra">PMID:12524274</ref><ref group="xtra">PMID:9655831</ref><ref group="xtra">PMID:9858744</ref><references group="xtra"/>
 [[Category: Emericellopsis sp. 2723]]
-[[Category: Driscoll, P C.]]
+[[Category: Large Structures]]
-[[Category: Galbraith, T P.]]
+[[Category: Driscoll PC]]
-[[Category: Harris, R.]]
+[[Category: Galbraith TP]]
-[[Category: Wallace, B A.]]
+[[Category: Harris R]]
-[[Category: Antibiotic]]
+[[Category: Wallace BA]]
-[[Category: Ion channel]]
-[[Category: Membrane polypeptide]]
-[[Category: Peptaibol]]