Glucagon: Difference between revisions
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== Relevance == | == Relevance == | ||
Glucagon is injected in cases of severe | Glucagon is injected in cases of severe hypoglycemia<ref>PMID:15793249</ref>. It has to be reconstituted from lyophilized glucagon because in solution it quickly aggregates to form <scene name='46/460279/Fibrill/1'>insoluble fibrils</scene><ref>PMID:31235909</ref>. Overdose of β blockers is treated with GLCas well as cases of epinephrine-resistant low blood pressure. Pancreatic tumors may cause high levels of GLC. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of glucagon == | == 3D Structures of glucagon == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
'''Human glucagon residues 53-81''' | |||
[[1kx6]], [[2m5p]], [[2m5q]], [[6nzn]] – hGLC - NMR<br /> | [[1kx6]], [[2m5p]], [[2m5q]], [[6nzn]] – hGLC - NMR<br /> | ||
[[1nau]] – hGLC (mutant) – NMR<br /> | [[1nau]] – hGLC (mutant) – NMR<br /> | ||
[[5otu]], [[5otv]], [[5otw]], [[5otx]] – hGLC (mutant) + GLC-like peptide 1 receptor <br /> | |||
[[6phj]], [[6pho]] – hGLC preprotein <br /> | [[6phj]], [[6pho]] – hGLC preprotein <br /> | ||
[[6phm]], [[6phq]] – D-hGLC preprotein<br /> | [[6phm]], [[6phq]] – D-hGLC preprotein<br /> | ||