2ruq: Difference between revisions

<StructureSection load='2ruq' size='340' side='right'caption='[[2ruq]]' scene=''>

<table><tr><td colspan='2'>[[2ruq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RUQ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ruq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ruq OCA], [https://pdbe.org/2ruq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ruq RCSB], [https://www.ebi.ac.uk/pdbsum/2ruq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ruq ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jing W]]

[[Category: Tate S]]

[[Category: Tochio N]]