4cyk: Difference between revisions

<StructureSection load='4cyk' size='340' side='right'caption='[[4cyk]]' scene=''>

<table><tr><td colspan='2'>[[4cyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyk OCA], [https://pdbe.org/4cyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyk RCSB], [https://www.ebi.ac.uk/pdbsum/4cyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyk ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PAN3_YEAST PAN3_YEAST] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs.. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PAB1. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.<ref>PMID:8816488</ref> <ref>PMID:1358757</ref> <ref>PMID:9774670</ref> <ref>PMID:11953437</ref> <ref>PMID:15894541</ref>  

[[Category: Allen MD]]

[[Category: Bycroft M]]

[[Category: Gordiyenko Y]]

[[Category: McLaughlin SH]]

[[Category: Meineke B]]

[[Category: Olsen TM]]

[[Category: Passmore LA]]

[[Category: Robinson CV]]

[[Category: Stewart M]]

[[Category: Valkov E]]

[[Category: Wolf J]]