Gephyrin: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='4u91' size='340' side='right' caption='Rat gephyrin E domain (grey) complex with glycine receptor peptide (green) (PDB code 4u91)' scene=''> == Function == '... |
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<StructureSection load='4u91' size='340' side='right' caption='Rat gephyrin E domain (cyan) complex with glycine receptor peptides (magenta and pink), acetate and Ca+2 ion (green) (PDB code [[4u91]])' scene='80/800120/Cv/4'> | |||
<StructureSection load='4u91' size='340' side='right' caption='Rat gephyrin E domain ( | |||
== Function == | == Function == | ||
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== Relevance == | == Relevance == | ||
Abnormal accumulation of Gep are highly correlated with the neuropathologic | Abnormal accumulation of Gep are highly correlated with the neuropathologic diagnosis of Alzheimer Disease<ref>PMID:24128675</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
<scene name='80/800120/Cv/5'>Para-Phenyl crosslinked Glycine receptor beta subunit derived dimeric peptide</scene> interacts with <scene name='80/800120/Cv/8'>several side chains of Gep</scene><ref>PMID:25413248</ref>. | |||
*<scene name='80/800120/Cv/7'>1,1'-benzene-1,4-diylbis(1H-pyrrole-2,5-dione) crosslinking with peptides</scene> | |||
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[[2fu3]], [[5erq]], [[4pd0]] - rGeph E domain 318-736 - rat<br /> | [[2fu3]], [[5erq]], [[4pd0]] - rGeph E domain 318-736 - rat<br /> | ||
[[2fts]], [[4pd1]], [[1t3e]], [[4u91]] - rGeph E domain + glycine receptor peptide<br /> | [[2fts]], [[4pd1]], [[1t3e]], [[4u91]] - rGeph E domain + glycine receptor peptide<br /> | ||
[[6hso]] - rGeph E domain + glycine receptor peptide + ADP<br / | |||
[[4tk1]], [[4tk2]], [[4tk3]], [[4tk4]], [[4u90]] - rGeph E domain + GABA receptor peptide<br /> | [[4tk1]], [[4tk2]], [[4tk3]], [[4tk4]], [[4u90]] - rGeph E domain + GABA receptor peptide<br /> | ||
[[6hsn]] - rGeph E domain + GABA receptor peptide + ADP<br /> | |||
[[5ers]] - rGeph E domain + AMP<br /> | [[5ers]] - rGeph E domain + AMP<br /> | ||
[[5ert]], [[5err]] - rGeph E domain + ADP<br /> | [[5ert]], [[5err]] - rGeph E domain + ADP<br /> | ||
[[5eru]] - rGeph E domain + ADP + Mo + MoO4<br /> | [[5eru]] - rGeph E domain + ADP + Mo + MoO4<br /> | ||
[[5erv]] - rGeph E domain + ADP + W + WO4<br /> | [[5erv]] - rGeph E domain + ADP + W + WO4<br /> | ||
[[ | [[6fgc]] - rGeph E domain + artesunate + ADP<br /> | ||
[[6fgd]] - rGeph E domain + artemether + ADP<br /> | |||
[[1ihc]], [[1jlj]] - rGeph N terminal<br /> | |||
[[1eav]] - rGeph G domain 462-623 – ''Arabidopsis thaliana''<br /> | |||
== References == | == References == | ||