Flavin reductase: Difference between revisions

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<StructureSection load='1he2' size='350' side='right' scene='' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
<StructureSection load='' size='350' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>


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== Function ==
== Function ==


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== Structural insights ==
== Structural insights ==


The NADP containing active site can accommodate a variety of ligands because the binding is achieved via mainly hydrophobic interactions.
The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
</StructureSection>
</StructureSection>


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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*NADPH-dependent Flavin reductase or biliverdin IX beta reductase
**[[1hdo]], [[7er6]] - hFR + NADP - human<br />
**[[6opl]] – hFR (mutant) + NADP <br />
**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
**[[1he4]] - hFR + FMN + NADP<BR />
**[[1he5]] - hFR + lumichrome + NADP<BR />
**[[5ooh]] – hFR + NADP + erythrosine<br />
**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
**[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br />
**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
**[[5cho]] - FR + FAD – uncultured bacteria<br />
**[[1qfj]] – FR – ''Escherichia coli''<br />
**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
**[[2bkj]] - VhFR + NAD + FMN<br />
*NADH-dependent Flavin reductase


[[1qfj]] – FR – ''Escherichia coli''<br />
**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
**[[1rz1]] - GtFR + FAD + NAD<br />
[[2bkj]] - VhFR + NAD + FMN<br />
**[[5n6q]] - PpFR + FMN – ''Pseudomonas putida''<br />
[[1hdo]] - hFR + NADP - human<br />
**[[4uth]] - PpFR (mutant) + FMN <br />
[[1he2]] - hFR + biliverdin IX α + NADP<BR />
**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
**[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br />
[[1he4]] - hFR + FMN + NADP<BR />
**[[2d37]] - StFR + FMN + NAD<br />
[[1he5]] - hFR + lumichrome + NADP<BR />
**[[2d38]] - StFR + FMN + NADP<br />
[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
[[1rz1]] - GtFR + FAD + NAD<br />
[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''


}}
== References ==
== References ==
<references/>
<references/>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman