Flavin reductase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<!--
+<StructureSection load='' size='350' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
-Or use the four-green-boxes-button to insert scrollable text adjacent
+== Function ==
-to a Jmol applet. Check out the other buttons as well!
--->
+'''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin.  FR is involved in heme catabolism<ref>PMID:7400118</ref> .
-'''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin.  This reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia.  FR is involved in heme catabolism
+== Relevance ==
+FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia.  Bacterial FR are used to sensitize tumors to drugs.
+== Structural insights ==
+The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
+</StructureSection>
 ==3D structures of flavin reductase==
-[[1qfj]] – FR – ''Escherichia coli''<br />
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[2bkj]] - VhFR + NAD + FMN<br />
-[[1hdo]] - hFR + NADP - human<br />
+*NADPH-dependent Flavin reductase or biliverdin IX beta reductase
-[[1he2]] - hFR + biliverdin IX α + NADP<BR />
-[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
+**[[1hdo]], [[7er6]] - hFR + NADP - human<br />
-[[1he4]] - hFR + FMN + NADP<BR />
+**[[6opl]] – hFR (mutant) + NADP <br />
-[[1he5]] - hFR + lumichrome + NADP<BR />
+**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
-[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
+**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
-[[1rz1]] - GtFR + FAD + NAD<br />
+**[[1he4]] - hFR + FMN + NADP<BR />
-[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''
+**[[1he5]] - hFR + lumichrome + NADP<BR />
+**[[5ooh]] – hFR + NADP + erythrosine<br />
+**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
+**[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br />
+**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
+**[[5cho]] - FR + FAD – uncultured bacteria<br />
+**[[1qfj]] – FR – ''Escherichia coli''<br />
+**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
+**[[2bkj]] - VhFR + NAD + FMN<br />
+*NADH-dependent Flavin reductase
+**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
+**[[1rz1]] - GtFR + FAD + NAD<br />
+**[[5n6q]] - PpFR + FMN – ''Pseudomonas putida''<br />
+**[[4uth]] - PpFR (mutant) + FMN <br />
+**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
+**[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br />
+**[[2d37]] - StFR + FMN + NAD<br />
+**[[2d38]] - StFR + FMN + NADP<br />
+}}
+== References ==
+<references/>
+[[Category:Topic Page]]