4r6a: Difference between revisions

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-'''Unreleased structure'''
-The entry 4r6a is ON HOLD
+==Crystal structure of human TLR8 in complex with Hybrid-2==
+<StructureSection load='4r6a' size='340' side='right'caption='[[4r6a]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4r6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R6A FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=HB2:1-(4-AMINO-2-BUTYL-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL)-2-METHYLPROPAN-2-OL'>HB2</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6a OCA], [https://pdbe.org/4r6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r6a RCSB], [https://www.ebi.ac.uk/pdbsum/4r6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r6a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
-Authors: Tanji, H., Ohto, U., Shimizu, T.
+==See Also==
+*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
-Description: Crystal structure of human TLR8 in complex with Hybrid-2
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ohto U]]
+[[Category: Shimizu T]]
+[[Category: Tanji H]]