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Fatty acid synthase 3D structures: Difference between revisions

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


*Fatty acid synthase
*Fatty acid synthase; Domains – KS-MAT 2-963; MAT 422-823; enoyl-ACP-reductase 1529-1867; ACP 2114-2202; thioesterase 2221-2502


**[[1xkt]], [[4z49]] – hFAS thioesterase domain – human<br />
**[[1xkt]], [[4z49]] – hFAS thioesterase domain – human<br />
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**[[2cf2]], [[2vz8]] – pFAS – pig<br />
**[[2cf2]], [[2vz8]] – pFAS – pig<br />
**[[2png]] – FAS ACP domain – rat<br />
**[[2png]] – FAS ACP domain – rat<br />
**[[5my2]] – FAS  DI domain – mouse<br />
**[[5my2]] – FAS  KS-MAT DI domain – mouse<br />
**[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br />
**[[6fn6]] – FAS  – ''Drosophila melanogaster''<br />
**[[2uv8]], [[3hmj]], [[6ql9]] – yFAS α+β subunits - yeast<br />
**[[6jsh]], [[6jsi]], [[6ql5]], [[6ql6]], [[6ta1]], [[6u5t]], [[6u5u]], [[6wc7]] - yFAS α+β subunits – Cryo EM<br />
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br />
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br />
**[[6fn6]] – FAS  – ''Drosophila melanogaster''<br />
**[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br />
**[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR<br />
**[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
**[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br />
**[[4v8w]], [[6gjc]] – MtFAS I – Cryo-EM<br />
**[[4v8w]], [[6gjc]] – MtFAS I – Cryo-EM<br />
**[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
**[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br />
**[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br />
**[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br />
**[[6u5v]], [[6u5w]], [[7tui]] - CaFAS α+β subunits + FMN – ''Candida albicans'' - Cryo EM<br />
**[[7bc4]] - PpFAS α+β subunits – ''Pischia pastoris'' - Cryo EM<br />
**[[7bc5]] - PpFAS α subunit ACP domain - Cryo EM<br />
**[[7q5s]] - FAS – ''Chaetonium thermophilum'' - Cryo EM<br />


*FAS complex with fatty acid
*FAS complex with fatty acid


**[[3tjm]] – hFAS thioesterase domain + fatty acid<br />
**[[3tjm]] – hFAS thioesterase domain + fatty acid<br />
**[[2fae]] – EcFAS ACP domain + decanethioate<br />
**[[2fad]] – EcFAS ACP domain + heptanthioate<br />
**[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br />
**[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br />
**[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br />
**[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br />
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*FAS complex with reactants
*FAS complex with reactants


**[[2jfk]] – hFAS + malonyl CoA<br />
**[[2jfk]] – hFAS MAT domain + malonyl CoA<br />
**[[2vz9]] – pFAS + NADP<BR />
**[[2vz9]] – pFAS + NADP<BR />
**[[5my0]] - mFAS + malonyl CoA<br />
**[[5my0]] - mFAS KS-MAT domain + malonyl CoA<br />
**[[6rop]] - mFAS KS-MAT domain + octanoyl CoA<br />
**[[2wat]] – yFAS α subunit + CoA<br />
**[[2wat]] – yFAS α subunit + CoA<br />
**[[4v59]] – TlFAS + NADP<BR />
**[[4v59]] – TlFAS + NADP<BR />
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**[[2cg5]] - hFAS ACP domain + AASD-PPT<br />
**[[2cg5]] - hFAS ACP domain + AASD-PPT<br />
**[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br />
**[[6ql7]] – yFAS α+β subunits + translation machinery-associated protein 17<br />
**[[3ejb]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme<br />
**[[3ejb]], [[3eje]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid<br />


*FAS complex with inhibitor
*FAS complex with inhibitor


**[[7mhd]], [[7mhe]] – hFAS thioesterase domain + inhibitor<br />
**[[2px6]] – hFAS thioesterase domain + orlistat<br />
**[[2px6]] – hFAS thioesterase domain + orlistat<br />
**[[4piv]], [[5c37]], [[6nna]] – hFAS (mutant) + NADP + inhibitor<br />
**[[4piv]], [[5c37]], [[6nna]] – hFAS (mutant) + NADP + inhibitor<br />
**[[2vkz]] - yFAS α+β subunits + cerulenin<br />
**[[2vkz]] - yFAS α+β subunits + cerulenin<br />
For FAS acyl carrier protein see [[Acyl carrier protein]]
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[[Category:Topic Page]]

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Michal Harel
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