ExbB: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Laura McCauley, Michal Harel

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-ExbB is essential for TonB-dependent energy transduction as the absence of ExbB prevents TonB responding to the proton motive force, as well as the change of the high-affinity association of TonB for the outer membrane to the cytoplasmic membrane. <ref name='Held'>PMID: 12193634</ref>
+<StructureSection load='5zfu' size='350' side='right' caption='ExbB pentamer complex with ExbD peptide (red) (PDB code [[5zfu]])' scene=''>
+[[Image:ExbB.jpg|300px|right|thumb| The Structure of ExbB<ref name='Kampfenkel'>PMID: 8449962</ref>]]
+== Structure==
+'''ExbB''' consists of three transmembrane domains (spanning from residues 16-39, 128-155 and 162-194), with two large portions of the protein representing the majority of the protein in the cytoplasm and two smaller portions in the periplasm<ref name='Kampfenkel'>PMID: 8449962</ref>.
+ExbB can exist in the [[TonB]] system either in a complex with [[ExbD]] (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB<ref name='Held'>PMID: 12193634</ref>.
+ExbB has a similar sequence and physiological structure to [[TolQ]] and is therefore thought to be evolutionarily linked<ref name='Braun'>PMID: 15205446</ref>.
+==Function==
+ExbB is essential for TonB-dependent energy transduction as the absence of ExbB prevents TonB responding to the proton motive force, as well as the change of the high-affinity association of TonB for the outer membrane to the cytoplasmic membrane<ref name='Held'>PMID: 12193634</ref>.
-ExbB can exist in the TonB system either in a complex with [[ExbD]] (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB.<ref name='Held'>PMID: 12193634</ref>
+Loss of ExbB function can be partially replaced by TolQ and vice versa - reduced activities of either of these proteins via a mutant form can be reversed by introducing double mutants<ref name='Braun'>PMID: 15205446</ref>.
+</StructureSection>
+==3D structures of ExbB==
-== Structure==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[Image:ExbB.jpg|300px|right|thumb| The Structure of ExbB<ref name='Kampfenkel'>PMID: 8449962</ref>]]
-ExbB consists of three transmembrane domains (spanning from residues 16-39, 128-155 and 162-194), with two large portions of the protein representing the majority of the protein in the cytoplasm and two smaller portions in the periplasm.<ref name='Kampfenkel'>PMID: 8449962</ref>
+[[5zfu]], [[5zfv]] – EcExbB + ExbD peptide – ''Escherichia coli'' – Cryo EM<br />
+[[6tyi]] – EcExbB + ExbD – Cryo EM<br />
+[[5sv1]] – ExbB + ExbD peptide <br />
+[[5sv0]], [[5zfp]] – EcExbB <br />
+[[6ye4]] – SmExbB – ''Serratia marsescens'' - Cryo EM<br />
+[[7ajq]] – SmExbB + ExbD - Cryo EM<br />
 == References==
 <references/>
+[[Category:Topic Page]]