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Eukaryotic initiation factor 3D structures: Difference between revisions

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**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
**[[6ybw]] – hEIF1A in 48S ribosome – Cryo EM<br />
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[6yal]], [[6yan]] – rEIF1A+rEIF2A+EIF2C in 48S ribosome – Cryo EM<br />
**[[2ogh]] - yEIF1 – yeast - NMR<BR />
**[[2ogh]] - yEIF1 – yeast - NMR<BR />
**[[3j80]], [[3j81]], [[4uer]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
**[[3j80]], [[3j81]], [[4uer]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />


*EIF2
*EIF2


**[[1kl9]], [[1q8k]], [[5oa9]] – hEIF2A subunit 1<BR />
**[[1kl9]], [[1q8k]] – hEIF2A subunit α<BR />
**[[1q8x]] – hEIF2A - NMR<BR />
**[[3ecs]] – hEIF2B subunit α<br />
**[[3ecs]] – hEIF2B<br />
**[[7d46]], [[7l70]] – hEIF2B subunits α,β,γ,δ,ε – Cryo EM <br />
**[[6ezo]] – hEIF2B + drug <br />
**[[6ezo]] – hEIF2B subunits α,β,γ,δ,ε + drug <br />
**[[6o9z]], [[6o85]], [[6o81]], [[6k72]], [[6k71]], [[6i7t]] – hEIF2B + hEIF2 – Cryo EM <br />
**[[6o9z]], [[6o85]], [[6o81]], [[6k72]], [[6k71]], [[6i7t]], [[6k71]], [[6k72]], [[6o81]], [[6o85]], [[6o9z]], [[7d43]], [[7d44]], [[7d45]] – hEIF2B subunits α,β,γ,δ,ε + hEIF2 subunits α,β,γ – Cryo EM <br />
**[[7kmf]] – hEIF2B subunits α,β,γ,δ,ε + fructofuranose – Cryo EM <br />
**[[7l7g]] – hEIF2B subunits α,β,γ,δ,ε + inhibitor – Cryo EM <br />
**[[5oa9]] – hEIF2D <br />
**[[5w2f]] – hEIF2D C-terminal <br />
**[[5w2f]] – hEIF2D C-terminal <br />
**[[5oa3]] – hEIF2D in 40S ribosome – Cryo EM <br />
**[[5oa3]] – hEIF2D in 40S ribosome – Cryo EM <br />
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**[[3wj9]] - EIF2A – fission yeast<br />
**[[3wj9]] - EIF2A – fission yeast<br />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
**[[6i3m]] – yEIF2B + yEIF2 – Cryo EM <br />
**[[1paq]] – yEIF2B e subunit catalytic domain  524-712 <br />
**[[6i3m]], [[6qg0]], [[6qg1]], [[6qg2]], [[6qg3]], [[6qg5]], [[6qg6]] – yEIF2B + yEIF2 – Cryo EM <br />
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[3wj9]] - fyEIF2A – fission yeast<br />
**[[3wj9]] - fyEIF2A – fission yeast<br />
**[[6jlz]], [[6jly]] - fyEIF2A + EIF2B<br />
**[[6jlz]], [[6jly]] - fyEIF2A + EIF2B<br />
**[[6i5m]] – SsEIF2 subunit γ + GDP – ''Sulfolobus solfataricus''<br />
**[[6h6k]], [[6r8s]], [[6r8t]] – SsEIF2 subunit γ (mutant) + GDP <br />
**[[2a0u]] – EIF2B – ''Leihmania major'' <br />


*EIF2C or argonaute  
*EIF2C or argonaute  


**[[5w6v]] – hEI2C1 + RNA + GW182<br />
**[[5w6v]] – hEI2C1 + RNA + GW182<br />
**[[3luk]] – hEI2C2 mid domain<br />
**[[3luk]] – hEI2C2 mid domain 439-575 <br />
**[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C mid domain + nucleotide<br />
**[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C mid domain + nucleotide<br />
**[[5t7b]], [[5ki6]], [[4f3t]], [[6ra4]] – hEI2C2 + RNA<br />
**[[5t7b]], [[5ki6]], [[4f3t]] – hEI2C2 + RNA<br />
**[[4z4i]], [[4z4h]], [[4z4g]], [[4z4f]], [[4z4e]], [[4z4d]], [[4z4c]], [[4w5t]], [[4w5r]], [[4w5q]], [[4w5o]], [[4w5n]], [[4ola]], [[6cbd]], [[5wea]], [[5js2]], [[5js1]], [[4olb]], [[6n4o]] – hEI2C2 (mutant) + RNA<br />
**[[6ra4]] – hEI2C2 PAZ domain 214-347+ RNA<br />
**[[4z4i]], [[4z4h]], [[4z4g]], [[4z4f]], [[4z4e]], [[4z4d]], [[4z4c]], [[4w5t]], [[4w5r]], [[4w5q]], [[4w5o]], [[4w5n]], [[4ola]], [[6cbd]], [[5wea]], [[5js2]], [[5js1]], [[4olb]], [[6n4o]], [[6mdz]], [[6mfn]], [[6mfr]], [[6n4o]], [[6nit]] – hEI2C2 (mutant) + RNA<br />
**[[5vm9]] – hEI2C3 + RNA<br />
**[[5vm9]] – hEI2C3 + RNA<br />
**[[6oon]] – hEI2C4 + RNA<br />


*EIF3
*EIF3


**[[6ybd]], [[6ybs]], [[6zvj]] - hEIF3 in 40S ribosome – cryo EM<br />
**[[3j8b]], [[3j8c]] - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM<br />
**[[3j8b]], [[3j8c]] - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM<br />
**[[5a5t]] - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM - rat<br />**[[4kxt]], [[4krf]], [[4kre]], [[1si2]], [[1si3]] – hEI2C1 + RNA<br />
**[[6ybt]] - hEIF3A + hEIF3B + hEIF3I – cryo EM<br />
**[[6ybv]] - hEIF3A + hEIF3B + hEIF3C + mRNA + initiator Met tRNA – cryo EM<br />
**[[5a5t]] - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM - rat<br />
**[[6zce]], [[6zu9]], [[7a1g]] - yEIF3 in 40S ribosome – cryo EM<br />
**[[4kxt]], [[4krf]], [[4kre]], [[1si2]], [[1si3]] – hEI2C1 + RNA<br />
**[[4k51]], [[4u1d]] - yEIF3A PCI domain<br />
**[[4k51]], [[4u1d]] - yEIF3A PCI domain<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
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**[[4u1f]] - yEIF3B middle domain<br />
**[[4u1f]] - yEIF3B middle domain<br />
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
**[[5h7u]] - yEIF3C residues 36-163<br />
**[[5h7u]] - yEIF3C residues 36-163<br />
Line 64: Line 81:


**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
**[[2hxy]] – hEIF4A-III<br />
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
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**[[3l6a]] - hEIF4GII CTD<BR />
**[[3l6a]] - hEIF4GII CTD<BR />
**[[1hu3]], [[3d3m]], [[4iul]] – hEIF4GII middle domain<br />
**[[1hu3]], [[3d3m]], [[4iul]] – hEIF4GII middle domain<br />
**[[6ozu]] – EIF4G5 MIF4G domain – ''Trypanosoma cruzi''<br />
**[[2dng]] – hEIF4H RNA recognition domain – NMR<br />
**[[2dng]] – hEIF4H RNA recognition domain – NMR<br />


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**[[4c9b]] - hEIF4A + CWC22<br />
**[[4c9b]] - hEIF4A + CWC22<br />
**[[5zbz]] - hEIF4A-I DEAD domain + sanguinarine<br />
**[[5zbz]] - hEIF4A-I DEAD domain + sanguinarine<br />
**[[7ppz]], [[7pq0]] - hEIF4A-I + Burkholderia lethal factor<br />
**[[5xln]] - hEIF4A-II + ThrRS<br />
**[[5xln]] - hEIF4A-II + ThrRS<br />
**[[5mqf]], [[6icz]] - hEIF4A in splicesome – Cryo EM<br />
**[[6yvh]] - hEIF4A-III + CWC22 + CWC27<br />
**[[5mqf]], [[5xjc]], [[5yzg]], [[6icz]], [[7w59]], [[7w5a]], [[7w5b]] - hEIF4A in splicesome – Cryo EM<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
**[[7ddx]] - mEIF4A-I + KANK1 - mouse<br />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<br />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<br />
**[[6fc3]] - yEIF4E + p20<br />
**[[6fc3]] - yEIF4E + p20<br />
**[[6fc2]], [[6fc1]] - yEIF4E + EAP1<br />
**[[6fc2]], [[6fc1]] - yEIF4E + EAP1<br />
**[[4axg]] - DmEIF4E + protein CUP – Drosophila melanogaster<br />
**[[4axg]] - DmEIF4E + protein CUP – ''Drosophila melanogaster''<br />
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-binding protein <br />
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-binding protein <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
Line 102: Line 124:


**[[5zc9]] - hEIF4A-I + RNA + ATP analog + drug<br />
**[[5zc9]] - hEIF4A-I + RNA + ATP analog + drug<br />
**[[6icz]], [[6qdv]], [[7a5p]] - hEIF4A-III in spliceosome – Cryo EM<br />
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
**[[4bea]], [[5zml]], [[5zk9]], [[5zk7]], [[5zk5]], [[5zjz]], [[5zjy]] - hEIF4E + stapled peptide<br />
**[[4bea]], [[5zml]], [[5zk9]], [[5zk7]], [[5zk5]], [[5zjz]], [[5zjy]] - hEIF4E + stapled peptide<br />
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide <br />
**[[6u06]], [[6u09]] - mEIF4E + inhibitor<br />
**[[6xki]] - mEIF4E + RNA + pateamine<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
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**[[3am7]], [[1wkw]] - hEIF4E + EIF4E-BP1 peptide + nucleotide<br />
**[[3am7]], [[1wkw]] - hEIF4E + EIF4E-BP1 peptide + nucleotide<br />
**[[1ej4]] - mEIF4E + EIF4E-BP1 peptide<br />
**[[1ej4]] - mEIF4E + EIF4E-BP1 peptide<br />
**[[5osx]], [[5m84]], [[5m83]], [[5m81]], [[5m80]], [[5m7z]], [[5m7x]], [[5m7w]], [[5m7v]], [[5j5y]], [[5j5o]] - mEIF4E + mRNA cap analog<br />
**[[5osx]], [[5m84]], [[5m83]], [[5m81]], [[5m80]], [[5m7z]], [[5m7x]], [[5m7w]], [[5m7v]], [[5j5y]], [[5j5o]], [[6ylt]], [[6ylv]] - mEIF4E + mRNA cap analog<br />
**[[6ylr]] - mEIF4E (mutant) + mRNA cap analog<br />
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
Line 140: Line 166:
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[6knd]], [[6kne]] – EIF5 CTD – ''Candida albicans''<br />
**[[6q84]] – yEIF5A + importin Kap122 + GTPase RAN + GTP<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbk]] – yEIF5B + yEIF1A<br />
**[[3wbk]] – yEIF5B + yEIF1A<br />
Line 147: Line 175:
*EIF6
*EIF6


**[[6lqm]], [[6lsr]], [[6lss]], [[6lu8]] – hEIF6 in pre-60S ribosome – cryo EM<br />
**[[1g62]] – yEIF6 <br />
**[[1g62]] – yEIF6 <br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman
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