Ets1: Difference between revisions
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<StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1' | <StructureSection load='1mdm' size='340' side='right' caption='Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (magenta) and MB-1 promoter DNA (PDB code [[1mdm]]).' scene='59/595751/Cv/1'> | ||
== Function == | == Function == | ||
'''Ets1 (E26 Transformation-Specific)''' or '''p54''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> . | |||
'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> . | |||
== Relevance == | == Relevance == | ||
Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells. | Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells. | ||
== Structural highlights == | == Structural highlights == | ||
Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | Ets1 contains an ETS domain (residues 332-415) which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) (residues 54-135) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | ||
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*Ets1 | *Ets1 | ||
**[[1gvj]] – hETS1 ETS and autoinhibitory domains - human<br /> | |||
**[[1md0]] – mETS1 ETS domain - mouse<br /> | **[[1md0]] – mETS1 ETS domain - mouse<br /> | ||
**[[1r36]] – mETS1 ETS and autoinhibitory domains - NMR<br /> | **[[1r36]] – mETS1 ETS and autoinhibitory domains - NMR<br /> | ||
**[[2jv3]], [[2kmd]] – mETS1 PNT domain - NMR<br /> | **[[2jv3]], [[2kmd]] – mETS1 PNT domain - NMR<br /> | ||
*Ets1 binary complexes | *Ets1 binary complexes | ||
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**[[3ri4]] – hETS1 residues 280-441 + TCR α promoter DNA <br /> | **[[3ri4]] – hETS1 residues 280-441 + TCR α promoter DNA <br /> | ||
**[[2stt]], [[2stw]] – hETS1 ETS domain + DNA - NMR<br /> | **[[2stt]], [[2stw]] – hETS1 ETS domain + DNA - NMR<br /> | ||
**[[1k79]], [[1k7a]] – mETS1 ETS domain + DNA containing GGAA | **[[1k79]], [[1k7a]] – mETS1 ETS domain + DNA containing GGAA<br /> | ||
**[[6da1]], [[6dat]] – mETS1 + SSR peptide <br /> | |||
*Ets1 | *Ets1 higher complexes | ||
**[[1k78]] – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR<br /> | **[[1k78]] – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR<br /> | ||
**[[4l0y]], [[4l0z]], [[4l18]] – hETS1 residues 296-441 + TCR α promoter DNA + RunT-related transcription factor<br /> | **[[4l0y]], [[4l0z]], [[4l18]] – hETS1 residues 296-441 + TCR α promoter DNA + RunT-related transcription factor<br /> | ||
**[[4lg0]] – hETS1 residues 280-441 + cadherin promoter DNA + forkhead box protein<br /> | **[[4lg0]] – hETS1 residues 280-441 + cadherin promoter DNA + forkhead box protein<br /> | ||
**[[1mdm]] – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA <br /> | |||
**[[3wu1]] – hETS1 276-441 (mutant) + RUNX1 + DNA <br /> | |||
**[[3wts]], [[3wtt]], [[3wtu]], [[3wtv]], [[3wtw]], [[3wtx]], [[3wty]] – hETS1 276-441 (mutant) + RUNX1 + CBF beta + DNA <br /> | |||
}} | }} | ||