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The | ==The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition== | ||
<StructureSection load='2m7h' size='340' side='right'caption='[[2m7h]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M7H FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7h OCA], [https://pdbe.org/2m7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m7h RCSB], [https://www.ebi.ac.uk/pdbsum/2m7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m7h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | |||
==See Also== | |||
*[[Disintegrin|Disintegrin]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Calloselasma rhodostoma]] | |||
[[Category: Large Structures]] | |||
[[Category: Chang Y]] | |||
[[Category: Chuang W]] | |||
Latest revision as of 16:33, 22 February 2023
The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 RecognitionThe C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition
Structural highlights
FunctionVM2RH_CALRH Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). See Also |
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