1yxq: Difference between revisions

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-[[Image:1yxq.png|left|200px]]
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+==Crystal structure of actin in complex with swinholide A==
-The line below this paragraph, containing "STRUCTURE_1yxq", creates the "Structure Box" on the page.
+<StructureSection load='1yxq' size='340' side='right'caption='[[1yxq]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1yxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YXQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SWI:SWINHOLIDE+A'>SWI</scene></td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxq OCA], [https://pdbe.org/1yxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yxq RCSB], [https://www.ebi.ac.uk/pdbsum/1yxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yxq ProSAT]</span></td></tr>
-{{STRUCTURE_1yxq|  PDB=1yxq  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Marine toxins targeting the actin cytoskeleton represent a new and promising class of anti-cancer compounds. Here we present a 2.0 A resolution structure of swinholide A, a marine macrolide, bound to two actin molecules. The structure demonstrates that the actin dimer in the complex does not represent a physiologically relevant entity, for the two actin molecules do not interact with each other. The swinholide A actin binding site is the same as that targeted by toxins of the trisoxazole family and numerous actin binding proteins, highlighting the importance of this site in actin polymerization. The observed structure reveals the mechanism of action of swinholide A and provides a structural framework about which to design new agents directed at the cytoskeleton.
-===Crystal structure of actin in complex with swinholide A===
+Structural basis of swinholide A binding to actin.,Klenchin VA, King R, Tanaka J, Marriott G, Rayment I Chem Biol. 2005 Mar;12(3):287-91. PMID:15797212<ref>PMID:15797212</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_15797212}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1yxq" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 15797212 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_15797212}}
-==About this Structure==
-[[1yxq]] is a 2 chain structure of [[Actin]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXQ OCA].
 ==See Also==
-*[[Actin]]
+*[[Actin 3D structures|Actin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:15797212</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Oryctolagus cuniculus]]
-[[Category: King, R.]]
+[[Category: King R]]
-[[Category: Klenchin, V A.]]
+[[Category: Klenchin VA]]
-[[Category: Marriott, G.]]
+[[Category: Marriott G]]
-[[Category: Rayment, I.]]
+[[Category: Rayment I]]
-[[Category: Tanaka, J.]]
+[[Category: Tanaka J]]
-[[Category: Actin]]
-[[Category: Contractile protein]]
-[[Category: Macrolide toxin]]
-[[Category: Swinholide some]]