Toll-like Receptors: Difference between revisions
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<StructureSection load='' size='340' side='right' caption='Glycosylated mouse toll-like receptor 3 dimer complex with double-stranded RNA [[3ciy]]' scene='Toll-like_Receptors/3ciynice/1' > | <StructureSection load='' size='340' side='right' caption='Glycosylated mouse toll-like receptor 3 dimer complex with double-stranded RNA [[3ciy]]' scene='Toll-like_Receptors/3ciynice/1' > | ||
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== Function == | == Function == | ||
'''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> See [[Inflammation & Rheumatoid Arthritis]]. The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]]. | '''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> See [[Inflammation & Rheumatoid Arthritis]]. The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]]. See also | ||
*[[Enzyme-linked receptor]] | |||
*[[TLR signaling pathway]] | |||
*'''TLR2''' is likely involved in specific B cell-mediated functions<ref>PMID:16766226</ref>.<br /> | *'''TLR2''' is likely involved in specific B cell-mediated functions<ref>PMID:16766226</ref>.<br /> | ||