4o1x: Difference between revisions

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'''Unreleased structure'''


The entry 4o1x is ON HOLD  until Paper Publication
==Crystal structure of human thymidylate synthase double mutant C195S-Y202C==
<StructureSection load='4o1x' size='340' side='right'caption='[[4o1x]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o1x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O1X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [https://pdbe.org/4o1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [https://www.ebi.ac.uk/pdbsum/4o1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o1x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>


Authors: Pozzi, C., Mangani, S.
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Mangani, S]]
__TOC__
[[Category: Pozzi, C]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mangani S]]
[[Category: Pozzi C]]

Latest revision as of 11:52, 18 January 2023

Crystal structure of human thymidylate synthase double mutant C195S-Y202CCrystal structure of human thymidylate synthase double mutant C195S-Y202C

Structural highlights

4o1x is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_HUMAN Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]

See Also

References

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

4o1x, resolution 2.32Å

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