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Factor IX: Difference between revisions

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The first cleavage is at Arg145, generating an inactive FIXα. The second cleavage is at Arg180 results in a catalytically active molecule FIXaβ. This resulting heterodimer is held by a disulfide bridge at Cys132-Cys289. The serine protease contains a catalytic triad of <scene name='Factor_IX/Ixstructure_catalytictriad/3'>His221, Asp269, and Ser365</scene><ref>PMID:9374470</ref>. Upon cleave at Arg180, Val181 can form a salt bridge with Asp364, which is a characteristic of active serine proteases. The active FIXa, can then interact with its cofactor, FVIIIa, to form a membrane-bound Xase complex, which activated FX to FXa.
The first cleavage is at Arg145, generating an inactive FIXα. The second cleavage is at Arg180 results in a catalytically active molecule FIXaβ. This resulting heterodimer is held by a disulfide bridge at Cys132-Cys289. The serine protease contains a catalytic triad of <scene name='Factor_IX/Ixstructure_catalytictriad/3'>His221, Asp269, and Ser365</scene><ref>PMID:9374470</ref>. Upon cleave at Arg180, Val181 can form a salt bridge with Asp364, which is a characteristic of active serine proteases. The active FIXa, can then interact with its cofactor, FVIIIa, to form a membrane-bound Xase complex, which activated FX to FXa.
For activated factor IX see [[Factor IXa]].


See [[Colored & Bioluminescent Protein]].<br />
See [[Colored & Bioluminescent Protein]].<br />
[[Mg-8 may contribute to the binding to factors VIIa and X]]<br />
[[Conformation-specific anti-Factor IX antibodies]].
[[Conformation-specific anti-Factor IX antibodies]].


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</StructureSection>
</StructureSection>
==3D structures of factor IX==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Factor IX
**[[1mgx]], [[1cfi]], [[1cfh]] - hIX GLA domain – human – NMR<br />
**[[1edm]] – hIX EGF-like domain<br />
**[[1ixa]] - hIX EGF-like domain - NMR
*Factor IX complexes
**[[3lc3]], [[3lc5]] – hIXa light+heavy chain + benzothiophene inhibitor<br />
**[[5vgy]] - hIXa residues 92-130 + trisaccharide<br />
**[[3kcg]] - hIXa light+heavy chains + antithrombin-III+ pentasaccharide<br />
**[[2wph]], [[2wpi]], [[2wpj]], [[2wpk]], [[2wpl]] - hIXa light+heavy chains (mutant) + FPR-chloromethyl ketone<br />
**[[2wpm]] - hIXa light+heavy chains (mutant) + EGR-chloromethyl ketone<br />
**[[1x7a]] - pIXa light+heavy chains + inhibitor – pig<br />
**[[1nl0]] – hIX GLA domain + anti-factor IX antibody<br />
**[[1j34]], [[1j35]] - hIX GLA domain + IX-binding protein – bovine<br />
**[[1rfn]] - hIXa light+heavy chains EGF2-catalytic domain + inhibitor<br />
**[[1pfx]] – pIXa +FPR<br />
**[[4yzu]], [[4z0k]], [[5tno]] – hIX peptidase S1 and EGF-like 2 domains + inhibitor <br />
**[[4zae]], [[5egm]], [[5jb8]], [[5jb9]], [[5jba]], [[5jbb]], [[5jbc]], [[5tnt]] – hIX peptidase S1 and EGF-like 2 domains (mutant) + inhibitor <br />
**[[4wm0]] – hIX residues 92-130 + xyloside gxylosyltransferase + glucopyranose derivative<br />
**[[4wma]] – hIX residues 92-130 + xyloside gxylosyltransferase + UDP-glucose <br />
**[[4wnh]] – hIX residues 92-130 + xyloside gxylosyltransferase + UDP-xylose <br />
**[[4wmb]] – hIX residues 92-130 + xyloside gxylosyltransferase + UDP <br />
**[[4wmi]], [[4wmk]], [[4wn2]] – hIX residues 92-130 + xyloside gxylosyltransferase + glucopyranose derivative + UDP<br />
**[[5fm6]] – hIX residues 92-130 + glucosyltransferase <br />
**[[5fm4]] – hIX residues 92-130 + glucosyltransferase + UDP-glucose <br />
**[[5fm5]] – hIX residues 92-130 + glucosyltransferase + UDP <br />
}}


==Additional Resources==
==Additional Resources==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Nadia Dorochko, Alexander Berchansky, David Canner, Michal Harel
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