Lipase: Difference between revisions
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* The '''bile salt-stimulated lipase''' (BSSL) is found in breast milk.<br /> | * The '''bile salt-stimulated lipase''' (BSSL) is found in breast milk.<br /> | ||
* The '''hormone-sensitive lipase''' (LIPE) hydrolyzes a variety of esters. For details see [[Hormone sensitive lipase]].<br /> | * The '''hormone-sensitive lipase''' (LIPE) hydrolyzes a variety of esters. For details see [[Hormone sensitive lipase]].<br /> | ||
* '''Monoacylglycerol lipase''' (MAGL) hydrolyzes intracellular triglycerides to fatty acid and glycerol. MAGL functions together with LIPE. For details see [[Monoglyceride lipase]]. | * '''Monoacylglycerol lipase''' (MAGL) hydrolyzes intracellular triglycerides to fatty acid and glycerol. MAGL functions together with LIPE. For details see [[Monoglyceride lipase]]. | ||
The reaction catalyzed by the enzyme is shown below. | The reaction catalyzed by the enzyme is shown below. | ||
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[[Image:Picture 1.png]] | [[Image:Picture 1.png]] | ||
Further breakdown ultimately results in 2-monoacylglycerols and free fatty acids <ref name= "A cross-linked complex between horse pancreatic lipase and colipase">[http://www.sciencedirect.com/science/article/pii/0014579389815923] A cross-linked complex between horse pancreatic lipase and colipase</ref>. An in depth discussion of the mechanism can be found in the Lipase Catalytic Mechanism section. The determination of the structure and function of lipase was a gradual process. Lipase activity was first demonstrated in the pancreas by Claude Bernard in 1846. However, it wasn't until 1955 that Mattson and Beck demonstrated a high-specificity of pancreatic lipase for triglyceride primary esters <ref name= "History of Lipids">[http://www.cyberlipid.org/history/history1.htm] History of Lipids</ref>. In recent years, determination of the crystal structure of pancreatic lipase has become the primary focus as many scientists have worked to further this.<br /> | Further breakdown ultimately results in 2-monoacylglycerols and free fatty acids <ref name= "A cross-linked complex between horse pancreatic lipase and colipase">[http://www.sciencedirect.com/science/article/pii/0014579389815923] A cross-linked complex between horse pancreatic lipase and colipase</ref>. An in depth discussion of the mechanism can be found in the Lipase Catalytic Mechanism section. The determination of the structure and function of lipase was a gradual process. Lipase activity was first demonstrated in the pancreas by Claude Bernard in 1846. However, it wasn't until 1955 that Mattson and Beck demonstrated a high-specificity of pancreatic lipase for triglyceride primary esters <ref name= "History of Lipids">[http://www.cyberlipid.org/history/history1.htm] History of Lipids</ref>. In recent years, determination of the crystal structure of pancreatic lipase has become the primary focus as many scientists have worked to further this.<br /> | ||
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==See also== | |||
* [[Molecular Playground/Pancreatic Lipase]]<br /> | * [[Molecular Playground/Pancreatic Lipase]]<br /> | ||
* [[Lipase lid morph]]<br /> | * [[Lipase lid morph]]<br /> | ||
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* [[Monoglyceride lipase]]<br /> | * [[Monoglyceride lipase]]<br /> | ||
* [[Human gastric lipase]]<br /> | * [[Human gastric lipase]]<br /> | ||
* [[Lipoprotein Lipase (LPL) complexed with GPIHBP1]]<br /> | |||
* [[Lipase (Hebrew)]]<br /> | * [[Lipase (Hebrew)]]<br /> | ||
* [[Lipid metabolism]] | |||
== '''Structure''' == | == '''Structure''' == | ||