Bile acid receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='3ruu' size='350' side='right' caption='Structure of human FXR ligand-binding domain (magenta) complex with non-steroidal agonist, nuclear receptor coactivator 1 peptide (cyan) and sulfate ions (PDB entry [[3ruu]])' scene='54/545859/Cv/1'>
+<StructureSection load='' size='350' side='right' caption='Structure of human FXR ligand-binding domain (magenta) complex with non-steroidal agonist, nuclear receptor coactivator 1 peptide (cyan) and sulfate ions (PDB entry [[3ruu]])' scene='54/545859/Cv/1'>
 == Function ==
-'''Bile acid receptor or farnesoid X receptor''' (FXR) binds bile acids, then translocates to the nucleus, forms a dimer and binds to hormone response elements.  This causes up- or down-regulation of certain genes involved in cholesterol metabolism, lipid homeostasis and absorption of fats and vitamins.  FXR ligand-binding domain (LBD) binds  chenodeoxycholic acid (CDC), lithocholic acid and deoxycholic acid. <ref>PMID:23982684</ref>
+'''Bile acid receptor or farnesoid X receptor''' (FXR) binds bile acids, then translocates to the nucleus, forms a dimer and binds to hormone response elements (see [[Nuclear receptors]]).  This causes up- or down-regulation of certain genes involved in cholesterol metabolism, lipid homeostasis and absorption of fats and vitamins.  FXR ligand-binding domain (LBD) binds  chenodeoxycholic acid (CDC), lithocholic acid and deoxycholic acid. <ref>PMID:23982684</ref>
+See also [[Intracellular receptors]]
 == Disease ==
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 == Structural highlights ==
-<scene name='54/545859/Cv/2'>Structure</scene> of human FXR ligand-binding domain (deeppink) complex with non-steroidal agonist, nuclear receptor coactivator 1 peptide (cyan) and sulfate ions (PDB entry [[3ruu]]). <ref>PMID:21890356</ref>
+<scene name='54/545859/Cv/3'>Structure</scene> of human FXR ligand-binding domain (deeppink) complex with non-steroidal agonist, nuclear receptor coactivator 1 peptide (cyan) and sulfate ions (PDB entry [[3ruu]]). <ref>PMID:21890356</ref>
-</StructureSection>
 ==3D structures of bile acid receptor==
+[[Bile acid receptor 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-[[1osh]], [[3fli]], [[3l1b]] – hFXR LBD + non-steroidal agonist - human <br />
-[[1osv]] – hFXR LBD + CDC derivative + nuclear receptor coactivator 2 peptide<br />
-[[4wvd]] - hFXR LBD + nuclear receptor corepressor peptide<br />
-[[3bej]], [[3dct]], [[3dcu]], [[3hc5]], [[3hc6]], [[3rut]], [[3ruu]], [[3rvf]] – hFXR LBD + non-steroidal agonist + nuclear receptor coactivator 1 peptide<br />
-[[4qe6]] – hFXR LBD + CDC + nuclear receptor coactivator 2 peptide<br />
-[[4qe8]] – hFXR LBD + DM175 + nuclear receptor coactivator 2 peptide<br />
-[[3fxv]], [[3gd2]], [[3okh]], [[3oki]], [[3olf]], [[3omk]], [[3omm]], [[3oof]], [[3ook]], [[3p88]], [[3p89]] – hFXR LBD (mutant) + non-steroidal agonist + nuclear receptor coactivator 1 peptide<br />
-[[1ot7]] – hFXR LBD + CDC derivative + RPGR-interacting protein peptide<br />
-[[4oiv]] – hFXR LBD + antagonist  <br />
 == References ==
 <references/>
 [[Category:Topic Page]]