Inhibitory neurosteroids: Difference between revisions

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Revision as of 12:02, 12 January 2023 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Latest revision as of 12:03, 12 January 2023 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary
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	<StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])''>		<StructureSection load='5osb' size='340' side='right' caption='Mouse GLIC-GABAA receptor complex with corticosterone derivative, acetate and Cl- ion (PDB code [[5osb]])'>
	These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.		These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects.