|
|
| (3 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| <StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | | <StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> |
| | |
| | __TOC__ |
| | |
| == Function == | | == Function == |
| [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> |
| Line 7: |
Line 10: |
| [[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> | | [[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> |
| * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | | * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> |
| * '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | | * '''TnI''' binds to actin which is found in thin muscle filaments. See [[Human Cardiac Troponin I]]<br /> |
|
| |
|
| == Disease == | | == Disease == |
| Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | | Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. |
| </StructureSection>
| | |
| == 3D Structures of Troponin == | | == 3D Structures of Troponin == |
|
| |
|
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[Troponin 3D structures]] |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| |
|
| |
|
| * Troponin C+Troponin I+Troponin T
| | </StructureSection> |
| | |
| **[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human<br />
| |
| **[[6kn8]], [[6kn7]] - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM<br />
| |
| **[[6klu]], [[6klt]] - mTnC + TnI + TnT – mouse - Cryo EM<br />
| |
| **[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br />
| |
| **[[1ytz]] - cTnC+cTnI+cTnT+Ca<br />
| |
| **[[1yv0]] - cTnC+cTnI+cTnT<br />
| |
| | |
| * Troponin C+Troponin I
| |
| | |
| **[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br />
| |
| **[[6mv3]] – hTnC/hTnI (mutant) – NMR<br />
| |
| **[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
| |
| **[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
| |
| **[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment - NMR<br />
| |
| **[[2n7l]] - hTnC N-terminal/hTnC switch + drug analog – NMR<br />
| |
| **[[2kgb]] – hTnC (mutant) regulatory domain+TnI - NMR<br />
| |
| **[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) - NMR<br />
| |
| **[[1a2x]] - rTnC +rTnI fragment – rabbit<br />
| |
| **[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br />
| |
| **[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
| |
| **[[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br />
| |
| **[[1jc2]] - cTnC C-terminal+cTnI N-terminal<br />
| |
| **[[3tz1]] - TnC C terminal +TnI fragment – akazara scallop<br />
| |
| | |
| * Troponin C
| |
| | |
| **[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
| |
| **[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
| |
| **[[3rv5]], [[3sd6]], [[3swb]], [[4gje]], [[1spy]] - hTnC N-terminal<br />
| |
| **[[4gjg]], [[5vln]] - hTnC N-terminal (mutant)<br />
| |
| **[[1ap4]] - hTnC N-terminal+Ca – NMR<br />
| |
| **[[2jxl]], [[2n79]] - hTnC N-terminal (mutant) + Ca – NMR<br />
| |
| **[[4gjf]] - hTnC N-terminal (mutant) + Cd<br />
| |
| **[[1wrk]], [[1wrl]] - hTnC N-terminal (mutant) +trifluoperazine<br />
| |
| **[[5w88]], [[5wcl]] - hTnC N-terminal (mutant) + methyldiphenylamine - NMR<br />
| |
| **[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
| |
| **[[2mle]] - hTnC C-terminal – NMR<br />
| |
| **[[2mlf]] - hTnC C-terminal (mutant) – NMR<br />
| |
| **[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
| |
| **[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
| |
| **[[1tcf]] – rTnC+Ca<br />
| |
| **[[1tn4]], [[2tn4]] – rTnC (mutant)+Ca<br />
| |
| **[[1la0]], [[4tnc]] – cTnC+Ca<br />
| |
| **[[1dtl]] – cTnC (mutant)+Ca +bepridil<br />
| |
| **[[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br />
| |
| **[[1aj4]] - cTnC (mutant) +Ca – NMR<br />
| |
| **[[3ctn]] - cTnC C-terminal – NMR<br />
| |
| **[[1avs]] - cTnC N-terminal+Ca<br />
| |
| **[[1smg]], [[1tnq]] - cTnC N-terminal+Ca - NMR<br />
| |
| **[[1ncy]] – cTnC+Mn<br />
| |
| **[[1ncx]], [[1ncz]], [[1top]] – cTnC<br />
| |
| **[[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br />
| |
| **[[1tnp]] - cTnC N-terminal – NMR<br />
| |
| **[[1tnw]], [[1tnx]] - cTnC +Ca - NMR<br />
| |
| **[[1trf]] - tTnC N-terminal+Ca - turkey – NMR<br />
| |
| **[[5tnc]] - tTnC<br />
| |
| **[[2k2a]] - TnC C-terminal – ''Lethocerus indicus'' – NMR<br />
| |
| **[[2jnf]] – TnC – fly – NMR<br />
| |
| **[[1r2u]], [[1r6p]] - TnC N-terminal – trout – NMR<br />
| |
| | |
| * Troponin I
| |
| | |
| **[[2jpw]] – mTnI biphosphorylated – NMR<br />
| |
| **[[1vdi]] – cTnI – NMR<br />
| |
| **[[1vdj]] – cTnI+Ca - NMR
| |
| | |
| * Troponin T
| |
|
| |
|
| **[[2z5h]] – yTnT fragment+tropomyosin – yeast
| |
| }}
| |
| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |