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| <StructureSection load='1yv0' size='340' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | | <StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> |
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| | __TOC__ |
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| == Function == | | == Function == |
| [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> |
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| [[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> | | [[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> |
| * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> | | * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> |
| * '''TnI''' binds to actin which is found in thin muscle filaments.<br /> | | * '''TnI''' binds to actin which is found in thin muscle filaments. See [[Human Cardiac Troponin I]]<br /> |
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| == Disease == | | == Disease == |
| Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | | Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. |
| </StructureSection>
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| == 3D Structures of Troponin == | | == 3D Structures of Troponin == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[Troponin 3D structures]] |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Troponin C+Troponin I+Troponin T
| | </StructureSection> |
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| **[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br />
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| **[[1ytz]] - cTnC+cTnI+cTnT+Ca<br />
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| **[[1yv0]] - cTnC+cTnI+cTnT<br />
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| **[[1j1d]], [[1j1e]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human
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| * Troponin C+Troponin I
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| **[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br />
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| **[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
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| **[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
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| **[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment - NMR<br />
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| **[[2n7l]] - hTnC N-terminal/hTnC switch + drug analog – NMR<br />
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| **[[2kgb]] – hTnC (mutant) regulatory domain+TnI - NMR<br />
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| **[[2mzp]] - hTnC regulatory domain+TnI switch region (mutant) - NMR<br />
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| **[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg - NMR<br />
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| **[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
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| **[[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br />
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| **[[1jc2]] - cTnC C-terminal+cTnI N-terminal<br />
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| **[[1a2x]] - rTnC +rTnI fragment – rabbit<br />
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| **[[3tz1]] - TnC C terminal +TnI fragment – akazara scallop<br />
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| * Troponin C
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| **[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
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| **[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
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| **[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
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| **[[2jxl]], [[2n79]] - hTnC (mutant) N-terminal + Ca – NMR<br />
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| **[[3rv5]], [[3sd6]], [[3swb]], [[4gje]] - hTnC N-terminal<br />
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| **[[4gjg]] - hTnC N-terminal (mutant)<br />
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| **[[4gjf]] - hTnC N-terminal (mutant) + Cd<br />
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| **[[1wrk]], [[1wrl]] - hTnC (mutant) N-terminal+trifluoperazine<br />
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| **[[1spy]] - hTnC N-terminal – NMR<br />
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| **[[2mle]] - hTnC C-terminal – NMR<br />
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| **[[2mlf]] - hTnC C-terminal (mutant) – NMR<br />
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| **[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
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| **[[1ap4]] - hTnC N-terminal+Ca – NMR<br />
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| **[[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
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| **[[1la0]], [[4tnc]] – cTnC+Ca<br />
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| **[[1dtl]] – cTnC (mutant)+Ca +bepridil<br />
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| **[[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br />
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| **[[1aj4]] - cTnC (mutant) +Ca – NMR<br />
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| **[[3ctn]] - cTnC C-terminal – NMR<br />
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| **[[1avs]] - cTnC N-terminal+Ca<br />
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| **[[1smg]], [[1tnq]] - cTnC N-terminal+Ca - NMR<br />
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| **[[1ncy]] – cTnC+Mn<br />
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| **[[1ncx]], [[1ncz]], [[1top]] – cTnC<br />
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| **[[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br />
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| **[[1tnp]] - cTnC N-terminal – NMR<br />
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| **[[1tnw]], [[1tnx]] - cTnC +Ca - NMR<br />
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| **[[1trf]] - tTnC N-terminal+Ca - turkey – NMR<br />
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| **[[5tnc]] - tTnC<br />
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| **[[2k2a]] - TnC C-terminal – ''Lethocerus indicus'' – NMR<br />
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| **[[2jnf]] – TnC – fly – NMR<br />
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| **[[1r2u]], [[1r6p]] - TnC N-terminal – trout – NMR<br />
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| **[[1tcf]] – rTnC+Ca<br />
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| **[[1tn4]], [[2tn4]] – rTnC (mutant)+Ca
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| * Troponin I
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| **[[2jpw]] – TnI biphosphorylated – mouse – NMR<br />
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| **[[1vdi]] – cTnI – NMR<br />
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| **[[1vdj]] – cTnI+Ca - NMR
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| * Troponin T
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| **[[2z5h]] – yTnT fragment+tropomyosin – yeast
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |