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| [[Image:1yv0.png|left|200px|thumb|Crystal Structure of Troponin [[1yv0]]]]
| | <StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> |
| {{STRUCTURE_1yv0| PDB=1yv0 | SIZE=400| SCENE=Troponin/Cv/1 |right|CAPTION=Troponin complex with Mg ion[[1yv0]] }}
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| [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions. TnT binds to [[Tropomyosin|tropomyosin]] and TnI binds to actin which is found in thin muscle filaments. The images at the left and at the right correspond to one representative Tn, ''i.e.'' the crystal structure of complex Troponin C/Troponin I/Troponin T ([[1yv0]]).
| | __TOC__ |
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| {{TOC limit|limit=2}}
| | == Function == |
| | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> |
| | * '''TnC''' causes conformational change in TnI when it binds to calcium ions<ref>PMID:26232335</ref>. For more details on TnC see<br /> |
| | [[ Role of Troponin C in decreased muscle sensitivity to calcium]]<br /> |
| | [[Human Cardiac Troponin C]]<br /> |
| | [[Human Cardiac Troponin C in complex with the Green Tea Polyphenol]]<br /> |
| | * '''TnT''' binds to [[Tropomyosin|tropomyosin]].<br /> |
| | * '''TnI''' binds to actin which is found in thin muscle filaments. See [[Human Cardiac Troponin I]]<br /> |
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| | == Disease == |
| | Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. |
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| == 3D Structures of Troponin == | | == 3D Structures of Troponin == |
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| ''Update December 2011''
| | [[Troponin 3D structures]] |
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| === Troponin C+Troponin I+Troponin T ===
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| [[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br />
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| [[1ytz]] - cTnC+cTnI+cTnT+Ca++<br />
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| [[1yv0]] - cTnC+cTnI+cTnT<br />
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| [[1j1d]], [[1j1e]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human
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| === Troponin C+Troponin I ===
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| [[2krd]] – hTnC+hTnI – NMR<br />
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| [[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
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| [[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br />
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| [[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br />
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| [[2kgb]] – hTnC (mutant) regulatory domain+TnI<br />
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| [[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR<br />
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| [[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
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| [[1npq]] - cTnC (mutant) N-terminal+cTnI fragment+rhodamine<br /> | |
| [[1jc2]] - cTnC C-terminal+cTnI N-terminal<br />
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| [[1a2x]] - rTnC +rTnI fragment – rabbit
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| === Troponin C ===
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| [[2kdh]] – hTnC+green tea polyphenol – NMR<br />
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| [[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
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| [[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
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| [[2jxl]] - hTnC (mutant) N-terminal – NMR<br />
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| [[3rv5]] - hTnC N-terminal<br />
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| [[1wrk]], [[1wrl]] - hTnC (mutant) N-terminal+trifluoperazine<br />
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| [[1spy]] - hTnC N-terminal– NMR<br />
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| [[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
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| [[1ap4]] - hTnC N-terminal+Ca++ – NMR<br />
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| [[2l98]] – hTnC EF-hand domains 3,4 + resveratrol<br />
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| [[1la0]], [[4tnc]] – cTnC+Ca++<br />
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| [[1dtl]] – cTnC (mutant)+Ca++ +bepridil<br />
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| [[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br />
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| [[1aj4]] - cTnC (mutant) +Ca++ – NMR<br />
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| [[3ctn]] - cTnC C-terminal – NMR<br />
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| [[1avs]] - cTnC N-terminal+Ca++<br />
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| [[1smg]], [[1tnq]] - cTnC N-terminal+Ca++ - NMR<br />
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| [[1ncy]] – cTnC+Mn++<br />
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| [[1ncx]], [[1ncz]], [[1top]] – cTnC<br />
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| [[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br />
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| [[1tnp]] - cTnC N-terminal – NMR<br />
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| [[1tnw]], [[1tnx]] - cTnC +Ca++ - NMR<br />
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| [[1trf]] - tTnC N-terminal+Ca++ - turkey – NMR<br />
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| [[5tnc]] - tTnC<br />
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| [[2k2a]] - TnC C-terminal – ''Lethocerus indicus'' – NMR<br />
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| [[2jnf]] – TnC – fly – NMR<br />
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| [[1r2u]], [[1r6p]] - TnC N-terminal – trout – NMR<br />
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| [[1tcf]] – rTnC+Ca++<br />
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| [[1tn4]], [[2tn4]] – rTnC (mutant)+Ca++
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| === Troponin I ===
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| [[2jpw]] – TnI biphosphorylated – mouse – NMR<br />
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| [[1vdi]] – cTnI – NMR<br />
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| [[1vdj]] – cTnI+Ca++ - NMR
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| === Troponin T ===
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| [[2z5h]] – yTnT fragment+tropomyosin – yeast
| | </StructureSection> |
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| | == References == |
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |