Fumarase: Difference between revisions
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<StructureSection load='4adl' size='350' side='right' caption='Fumarase tetramer complex with malate , [[4adl]]' scene=''> | |||
== Function == | == Function == | ||
'''Fumarase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to make | '''Fumarase''' or '''fumarase hydratase''' is used in the citric acid cycle to conduct a transition step in the production of energy to make NADH. It metabolizes fumarate in the cytosol, which becomes a byproduct of the urea cycle and amino acid catabolism. It catalyzes the addition of water to fumarate to make ''L''-malate. This is a reversible reaction<ref>PMID:16204892</ref>. See also:<br /> | ||
*[[Krebs cycle carbons]] | *[[Krebs cycle carbons]] | ||
*[[Krebs cycle importance]] | *[[Krebs cycle importance]] | ||
*[[Krebs cycle overview]] | *[[Krebs cycle overview]] | ||
*[[Krebs cycle reactions]] | |||
*[[Citric Acid Cycle]] | |||
*[[Krebs cycle step 7]] | *[[Krebs cycle step 7]] | ||
*[[Fumarase 2]] | |||
*[[Glyoxylate cycle]] | |||
==Other interesting information== | ==Other interesting information== | ||
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<scene name='User:Sydney_Park/Secondary_structure/1'>Secondary Structure</scene><br /> | <scene name='User:Sydney_Park/Secondary_structure/1'>Secondary Structure</scene><br /> | ||
<scene name='User:Sydney_Park/Leuthydro/1'>Hydrophilic</scene><br /> | <scene name='User:Sydney_Park/Leuthydro/1'>Hydrophilic</scene><br /> | ||
</StructureSection> | |||
==3D structures of fumarase== | ==3D structures of fumarase== | ||
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*Fumarase | *Fumarase | ||
**[[6ebt]] – hFUM (mutant) – human<br /> | |||
**[[3e04]], [[5d6b]], [[5upp]] – hFUM residues 44-510 - human<br /> | |||
**[[6ebt]], [[6v8f]], [[6vbe]] – hFUM (mutant)<br /> | |||
**[[1yfm]], [[6ku6]] – FUM (mutant) – yeast<br /> | |||
**[[3qbp]] – FUM – ''Mycobacterium marinum''<br /> | **[[3qbp]] – FUM – ''Mycobacterium marinum''<br /> | ||
**[[3no9]] – MtFUM II – ''Mycobacterium tuberculosis''<br /> | **[[3no9]] – MtFUM II – ''Mycobacterium tuberculosis''<br /> | ||
| Line 34: | Line 43: | ||
**[[3rd8]] – FUM II – ''Mycobacterium smegmatis''<br /> | **[[3rd8]] – FUM II – ''Mycobacterium smegmatis''<br /> | ||
**[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br /> | **[[3gtd]] – FUM II – ''Rickettsia prowazekii''<br /> | ||
**[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br /> | **[[2isb]] – FUM I – ''Archaeoglobus fulgidus''<br /> | ||
**[[1kq7]], [[1yfe]] - EcFUM II (mutant) – ''Escherichia coli''<br /> | **[[1kq7]], [[1yfe]], [[6os7]] - EcFUM II (mutant) – ''Escherichia coli''<br /> | ||
**[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br /> | **[[4hgv]] – FUM II – ''Sinorhizobium meliloti''<br /> | ||
**[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br /> | **[[3tv2]] – FUM II – ''Burkholderia pseudomallei''<br /> | ||
**[[1vdk]] – FUM II (mutant) – ''Thermus thermophilus''<br /> | **[[1vdk]] – FUM II (mutant) – ''Thermus thermophilus''<br /> | ||
**[[6n1m]] – FUM II – ''Legionella pneumophila''<br /> | |||
**[[7miw]] – FUM II – ''Elizabethakingia anophelis''<br /> | |||
**[[6u4o]] – FUM II – ''Schistosoma mansoni''<br /> | |||
**[[7c1c]] – MsFUM II – ''Mannheimia succiniciproducens''<br /> | |||
**[[6unz]] – LmFUM II – ''Leishmania major''<br /> | |||
*Fumarase binary complexes | *Fumarase binary complexes | ||
**[[1fur]] - EcFUM II (mutant) + malate<br /> | **[[1fur]] - EcFUM II (mutant) + malate<br /> | ||
**[[2fus]] - EcFUM II (mutant) + citrate<br /> | **[[6nz9]] - EcFUM II + citrate<br /> | ||
**[[2fus]], [[6nza]], [[6nzb]], [[6nzc]], [[6os7]], [[6p3c]] - EcFUM II (mutant) + citrate<br /> | |||
**[[4adl]] - MtFUM II + malate<br /> | **[[4adl]] - MtFUM II + malate<br /> | ||
**[[4adm]] - MtFUM II + tartrate<br /> | **[[4adm]] - MtFUM II + tartrate<br /> | ||
**[[4apb]] - MtFUM II (mutant) + fumarate | **[[4apb]] - MtFUM II (mutant) + fumarate<br /> | ||
**[[5f92]] – MtFUM II + formate<br /> | |||
**[[7c1a]] – MsFUM II + malate <br /> | |||
**[[7c18]] – MsFUM II + fumarate <br /> | |||
**[[6uo0]], [[6upm]], [[6upo]], [[6uq9]], [[6uql]], [[6uqm]] – LmFUM II (mutant) + malate <br /> | |||
**[[6uoi]] – LmFUM II + malonate <br /> | |||
**[[6up9]] – LmFUM II (mutant) + malonate <br /> | |||
**[[6uoj]] – LmFUM II + succinate <br /> | |||
*Fumarase ternary complexes | *Fumarase ternary complexes | ||
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**[[1fup]] - EcFUM II + pyromellitic acid + malate<br /> | **[[1fup]] - EcFUM II + pyromellitic acid + malate<br /> | ||
**[[1fuq]] - EcFUM II + pyromellitic acid + citrate<br /> | **[[1fuq]] - EcFUM II + pyromellitic acid + citrate<br /> | ||
**[[1fuo]] - EcFUM II + citrate + malate | **[[1fuo]] - EcFUM II + citrate + malate<br /> | ||
**[[5f91]], [[6s43]], [[6s7k]], [[6s7s]], [[6s7u]], [[6s7w]], [[6s7z]], [[6s88]] – MtFUM II + modulator + formate<br /> | |||
**[[6uqn]] – LmFUM II (mutant) + malate + fumarate <br /> | |||
**[[6uq8]], [[6uqb]] – LmFUM II (mutant) + malate + malonate <br /> | |||
}} | }} | ||
==References== | ==References== | ||
<references/> | |||
Wikipedia. <http://en.wikipedia.org/wiki/Fumarase>, Wikipedia. <http://en.wikipedia.org/wiki/Enolase>, University of Wisconsin- Eau Claire. <http://www.chem.uwec.edu/Webpapers_F99/Pages/Webpapers_F99/golnercm/Pages/descrip.html>, Virtual Chembook. Elmhurst College. <http://www.elmhurst.edu/~chm/vchembook/601glycolysisrx.html> | Wikipedia. <http://en.wikipedia.org/wiki/Fumarase>, Wikipedia. <http://en.wikipedia.org/wiki/Enolase>, University of Wisconsin- Eau Claire. <http://www.chem.uwec.edu/Webpapers_F99/Pages/Webpapers_F99/golnercm/Pages/descrip.html>, Virtual Chembook. Elmhurst College. <http://www.elmhurst.edu/~chm/vchembook/601glycolysisrx.html> | ||