Succinate Dehydrogenase: Difference between revisions
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<StructureSection load='3ae1' size='350' side='right' caption='Succinate dehydrogenase containing flavoprotein subunit (Sdha) (grey), iron-sulfur subunit (Sdhb) (green), cytochrome B560 subunit (Sdhc) (pink) and cytochrome B small subunit (Sdhd) (yellow), FAD, Fe2S2, Fe4S4 and Fe3S4 complex with protoporphyrin, malonate, benzamide derivative and α-phosphatidyl-β-oleoyl-γ-palmitoyl-phosphatidylethanolamine, [[3ae1]] ' scene=''> | <StructureSection load='3ae1' size='350' side='right' caption='Succinate dehydrogenase containing flavoprotein subunit (Sdha) (grey), iron-sulfur subunit (Sdhb) (green), cytochrome B560 subunit (Sdhc) (pink) and cytochrome B small subunit (Sdhd) (yellow), FAD, Fe2S2, Fe4S4 and Fe3S4 complex with protoporphyrin, malonate, benzamide derivative and α-phosphatidyl-β-oleoyl-γ-palmitoyl-phosphatidylethanolamine, [[3ae1]] ' scene=''> | ||
[[Image:Succinate Dehydrogenase.png|left|250px]] | [[Image:Succinate Dehydrogenase.png|left|250px]] | ||
{{Clear}} | |||
== Function == | == Function == | ||
[[Succinate Dehydrogenase]] (PDB = [[2wdv]] with empty ubiquinone binding site; PDB = [[1nek]] with ubiquinone bound), also called '''succinate-coenzyme Q reductase''' (SQR) or '''Complex II''', is a tetrameric enzyme found in the cell membrane of http://proteopedia.org/wiki/index.php?title=Succinate_Dehydrogenase&action=editsome bacteria and the inner mitochondrial membrane of mammalian cells. It is classified as an α+β protein, as it contains <scene name='Michael_Vick_Sandbox_2/2wdv_sec_structure/1'>segregated regions</scene> of α helices and antiparallel β sheets. It is involved in two aspects of digestion; it catalyzes the oxidation of succinate to fumarate in the [[The_Citric_Acid_Cycle|citric acid cycle]] by simultaneously reducing ubiquinone to ubiquinol in the electron transport chain <ref>PMID:14672929</ref>. See also:<br /> | [[Succinate Dehydrogenase]] (PDB = [[2wdv]] with empty ubiquinone binding site; PDB = [[1nek]] with ubiquinone bound), also called '''succinate-coenzyme Q reductase''' (SQR) or '''Complex II''', is a tetrameric enzyme found in the cell membrane of http://proteopedia.org/wiki/index.php?title=Succinate_Dehydrogenase&action=editsome bacteria and the inner mitochondrial membrane of mammalian cells. It is classified as an α+β protein, as it contains <scene name='Michael_Vick_Sandbox_2/2wdv_sec_structure/1'>segregated regions</scene> of α helices and antiparallel β sheets. It is involved in two aspects of digestion; it catalyzes the oxidation of succinate to fumarate in the [[The_Citric_Acid_Cycle|citric acid cycle]] by simultaneously reducing ubiquinone to ubiquinol in the electron transport chain <ref>PMID:14672929</ref>. See also:<br /> | ||
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*[[Krebs cycle importance]] | *[[Krebs cycle importance]] | ||
*[[Krebs cycle overview]] | *[[Krebs cycle overview]] | ||
*[[Krebs cycle reactions]] | |||
*[[Citric Acid Cycle]] | |||
*[[Krebs cycle step 6]] | *[[Krebs cycle step 6]] | ||
*[[Glyoxylate cycle]] | |||
==Structure== | ==Structure== | ||
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Since succinate dehydrogenase possesses multiple active sites that catalyze two different reactions, two classes of inhibitors function on the enzyme. The first class, which includes succinate analogs--both naturally-occuring TCA cycle intermediates like malate and oxaloacetate and the synthetic analog, malonate--contains some of the strongest succinate dehydrogenase inhibitors. The second class of inhibitors, which includes the ubiquinone analogs thenoyltrifluoroacetone and carboxin, binds to the ubiquinone active site and prevents reduction of the substrate<ref>PMID:17916065</ref>. | Since succinate dehydrogenase possesses multiple active sites that catalyze two different reactions, two classes of inhibitors function on the enzyme. The first class, which includes succinate analogs--both naturally-occuring TCA cycle intermediates like malate and oxaloacetate and the synthetic analog, malonate--contains some of the strongest succinate dehydrogenase inhibitors. The second class of inhibitors, which includes the ubiquinone analogs thenoyltrifluoroacetone and carboxin, binds to the ubiquinone active site and prevents reduction of the substrate<ref>PMID:17916065</ref>. | ||
==3D structures of succinate dehydrogenase== | ==3D structures of succinate dehydrogenase== | ||
[[Succinate dehydrogenase 3D structures]] | |||
</StructureSection> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||