Hexokinase: Difference between revisions
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== Function == | == Function == | ||
'''Hexokinase''' is an enzyme that phosphorylates a six-carbon sugar, a hexose, to a hexose phosphate. In most tissues and organisms, glucose is the most important substrate of hexokinases, and glucose 6-phosphate the most important product. Hexokinases have been found in every organism checked, ranging from bacteria, yeast, and plants, to humans and other vertebrates. They are categorized as actin fold proteins, sharing a common ATP binding site core surrounded by more variable sequences that determine substrate affinities and other properties. Several hexokinase isoforms or isozymes providing different functions can occur in a single species. See [[Glycolysis Enzymes]]. | '''Hexokinase''' is an enzyme that phosphorylates a six-carbon sugar, a hexose, to a hexose phosphate. In most tissues and organisms, glucose is the most important substrate of hexokinases, and glucose 6-phosphate the most important product. Hexokinases have been found in every organism checked, ranging from bacteria, yeast, and plants, to humans and other vertebrates. They are categorized as actin fold proteins, sharing a common ATP binding site core surrounded by more variable sequences that determine substrate affinities and other properties. Several hexokinase isoforms or isozymes providing different functions can occur in a single species. See [[Glycolysis Enzymes]], [[Glycogenesis]]. | ||
* '''Hexokinase I/A''' is found in all mammalian tissues, and is considered a "housekeeping enzyme," unaffected by most physiological, hormonal, and metabolic changes. More details in [[Hexokinase Type 1]]. | * '''Hexokinase I/A''' is found in all mammalian tissues, and is considered a "housekeeping enzyme," unaffected by most physiological, hormonal, and metabolic changes. More details in [[Hexokinase Type 1]]. | ||
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* '''Hexokinase IV/D''' is also known as '''glucokinase'''. | * '''Hexokinase IV/D''' is also known as '''glucokinase'''. | ||
Additional details in [[The Structure and Mechanism of Hexokinase]] and [[Conformational changes in proteins]] (in Spanish). | Additional details in [[The Structure and Mechanism of Hexokinase]], [[Glucokinase and Phosphorylase. Conformational changes (Spanish)]] and [[Conformational changes in proteins]] (in Spanish). | ||
== Structure of Hexokinase == | == Structure of Hexokinase == | ||