Interferon receptor: Difference between revisions

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<StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''>
<StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (yellow) complex with interferon-α 2 (pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''>
 
== Function ==
'''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br />
'''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br />
*  '''Interferon α/β receptor''' binds interferon-α and interferon-β.  It is a heterodimer with subunits INFAR1 and INFAR2.  For more details see [[IFNAR]] and [[Multiple sclerosis]].<br />
*  '''Interferon α/β receptor''' binds interferon-α and interferon-β.  It is a heterodimer with subunits INFAR1 and INFAR2<ref>PMID:17969444</ref>.  For more details see [[IFNAR]] and [[Multiple sclerosis]].<br />
*  '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2.<br />
*  '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2<ref>PMID:9462485</ref>.<br />
*  '''Interferon δ receptor''' binds interferon-δ.  
*  '''Interferon δ receptor''' binds interferon-δ<ref>PMID:9865499</ref>.  


</StructureSection>
See also: [[Cytokine receptors]].


==3D structures of interferon receptor==
== Relevance ==
Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice<ref>PMID:16451483</ref>.  Interferon α/β receptor deficiency has a role in the pathogenesis of lupus<ref>PMID:12642605</ref>.


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Disease ==
{{#tree:id=OrganizedByTopic|openlevels=0|
Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria<ref>PMID:10192386</ref>.


*Interferon α/β receptor
==3D structures of interferon receptor==
[[Interferon receptor 3D structures]]


**[[3s98]] – hINFAR1 ectodomain – human <br />
</StructureSection>
**[[1n6u]], [[1n6v]] – hINFAR2 ectodomain - NMR <br />
**[[3s8w]] – hINFAR2 D2 domain - NMR <br />
**[[2hym]], [[2kz1]], [[2lag]] – hINFAR2 ectodomain + interferon-α 2 - NMR <br />
**[[3s9d]] – hINFAR2 ectodomain + interferon-α 2  <br />
**[[3se3]] – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-α 2  <br />
**[[3se4]] – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-ω 1  <br />
**[[3wcy]] – INFAR1 ectodomain + interferon-β - mouse <br />
 
*Interferon γ receptor
 
**[[1jrh]] – hINFGR1 N terminal (mutant) + antibody  <br />
**[[1fg9]], [[1fyh]] – hINFGR1 extracellular domain + interferon-γ  <br />
**[[4eq2]], [[4eq3]] – INFGR1 α chain - chicken  <br />
 
*Interferon δ receptor


**[[3og4]], [[3og6]] – hINFDR1 extracellular domain + interleukin-29  <br />
== References ==
}}
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:37, 9 January 2023

Function

Interferon receptor (IFNR) is a cell surface receptor which binds interferon.

  • Interferon α/β receptor binds interferon-α and interferon-β. It is a heterodimer with subunits INFAR1 and INFAR2[1]. For more details see IFNAR and Multiple sclerosis.
  • Interferon γ receptor binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2[2].
  • Interferon δ receptor binds interferon-δ[3].

See also: Cytokine receptors.

Relevance

Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice[4]. Interferon α/β receptor deficiency has a role in the pathogenesis of lupus[5].

Disease

Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria[6].

3D structures of interferon receptor

Interferon receptor 3D structures


Structure of interferon α/β receptor β chain ectodomain (yellow) complex with interferon-α 2 (pink) and Cl- ion (green) (PDB entry 3s9d)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Uze G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316:71-95. PMID:17969444
  2. ↑ Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206. PMID:9462485
  3. ↑ Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-delta: the first member of a novel type I interferon family. Biochimie. 1998 Aug-Sep;80(8-9):779-88. PMID:9865499
  4. ↑ . PMID:16451483
  5. ↑ Santiago-Raber ML, Baccala R, Haraldsson KM, Choubey D, Stewart TA, Kono DH, Theofilopoulos AN. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med. 2003 Mar 17;197(6):777-88. PMID:12642605 doi:http://dx.doi.org/10.1084/jem.20021996
  6. ↑ Jouanguy E, Lamhamedi-Cherradi S, Lammas D, Dorman SE, Fondaneche MC, Dupuis S, Doffinger R, Altare F, Girdlestone J, Emile JF, Ducoulombier H, Edgar D, Clarke J, Oxelius VA, Brai M, Novelli V, Heyne K, Fischer A, Holland SM, Kumararatne DS, Schreiber RD, Casanova JL. A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet. 1999 Apr;21(4):370-8. PMID:10192386 doi:http://dx.doi.org/10.1038/7701

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