Proteopedia

Polycomb complex protein: Difference between revisions

← Older edit
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(3 intermediate revisions by 2 users not shown)
Line 2: Line 2:


== Function ==
== Function ==
'''Polycomb group ring finger protein 1''' (Pcgf1) is a link between Polycomb function and pluripotency <ref>PMID:26687479</ref>.<br />
'''Polycomb group ring finger protein 4''' (Pcgf4) or (BMI1) see below <ref>PMID:23523425</ref>.<br />
'''Polycomb group ring finger protein 5''' (Pcgf5) is regulator of gene expression and development <ref>PMID:29765032</ref>.<br />
'''Polycomb group ring finger protein 6''' (Pcgf6) has a role in safeguarding lineage decisions and in preventing aberrant expression of germ cell-related gens <ref>PMID:32482889</ref>.<br />


'''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development.
'''B-cell-specific Moloney leukemia virus insertion site 1''' (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development.
Line 93: Line 98:


==Polycomb complex protein 3D structures==
==Polycomb complex protein 3D structures==
 
[[Polycomb complex proteins 3D structures]]
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* Polycomb group ring finger protein 1 or Pcgf1
 
**[[4hpm]] – hPcgf1 167-255 + BCORL1 - human<br />
**[[4hpl]] – hPcgf1 167-255 + BCOR<br />
 
* BMI-1 or Polycomb group ring finger protein 4 or Pcgf4
**[[5fr6]] – hBMI1 residues 121-235 <br />
**[[2na1]] – hBMI1 residues 121-235 /polyhomeotic-like 2– NMR<br />
**[[6wi7]], [[8wi8]] – hBMI1 ring domain 1-108/Ring1B <br />
**[[7nd1]] – hBMI1 ring domain + Ring1B - NMR<br />
**[[3rpg]] – hBMI1 ring domain + Ring1B + Ubch5C<br />
**[[2ckl]] – mBMI1 ring domain + Ring1B - mouse<br />
**[[4r8p]] – BMI1 ring domain + Ring1B + Ubch5C + DNA - frog<br />
 
* Polycomb group ring finger protein 5 or Pcgf5
 
**[[4s3o]] – hPcgf5 ring domain 1-108 + Ring1B + Ubch5C<br />
 
* Polycomb group ring finger protein 6 or Pcgf
 
**[[2djb]] – hPcgf6 ring domain - NMR<br />
}}


== References ==
== References ==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Ricardo Alberto Chiong Zevallos, Michal Harel, Jaime Prilusky
Retrieved from "https://proteopedia.openfox.io/w/Polycomb_complex_protein"