Reverse Krebs cycle: Difference between revisions
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<StructureSection load='3pff' size='350' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'> | <StructureSection load='3pff' size='350' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'> | ||
The reverse Krebs cycle (also known as the reverse tricarboxylic acid cycle, the reverse TCA cycle, or the reverse citric acid cycle, or the reductive tricarboxylic acid cycle, or the reductive TCA cycle) is a sequence of chemical reactions that are used by some bacteria to produce carbon compounds from carbon dioxide and water by the use of energy-rich reducing agents as electron donors. See also [https://en.wikipedia.org/wiki/Reverse_Krebs_cycle] and [[Carbon Fixation]]. | The reverse Krebs cycle (also known as the reverse tricarboxylic acid cycle, the reverse TCA cycle, or the reverse citric acid cycle, or the reductive tricarboxylic acid cycle, or the reductive TCA cycle) is a sequence of chemical reactions that are used by some bacteria to produce carbon compounds from carbon dioxide and water by the use of energy-rich reducing agents as electron donors. See also [https://en.wikipedia.org/wiki/Biological_carbon_fixation], [https://en.wikipedia.org/wiki/Reverse_Krebs_cycle], and [[Carbon Fixation]]. | ||
The cycle involves the biosynthesis of <scene name='43/430893/Cv/2'>Acetyl-CoA</scene> from two molecules of CO2. The key steps of the reverse Krebs cycle are: | The cycle involves the biosynthesis of <scene name='43/430893/Cv/2'>Acetyl-CoA</scene> from two molecules of CO2. The key steps of the reverse Krebs cycle are: | ||
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α-Ketoglutarate + CO2 + NAD(P)H/H+ -> Isocitrate + NAD(P)+ | α-Ketoglutarate + CO2 + NAD(P)H/H+ -> Isocitrate + NAD(P)+ | ||
*<scene name='43/430893/Cv/4'>Citrate</scene> converted into <scene name='43/430893/Cv/3'>oxaloacetate</scene> and acetyl-CoA, this is an ATP dependent step and the key enzyme is the ATP citrate lyase | *<scene name='43/430893/Cv/4'>Citrate</scene> converted into <scene name='43/430893/Cv/3'>oxaloacetate</scene> and acetyl-CoA, this is an ATP dependent step and the key enzyme is the [[ATP-citrate synthase|ATP citrate lyase]]. | ||
Citrate + ATP + CoA -> Oxaloacetate + Acetyl-CoA + ADP + Pi | Citrate + ATP + CoA -> Oxaloacetate + Acetyl-CoA + ADP + Pi | ||