Transaldolase: Difference between revisions

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<StructureSection load='' size='400' side='right' scene='47/477090/Cv/1' caption='Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, [[3tno]]' pspeed='8'>
<StructureSection load='' size='400' side='right' scene='47/477090/Cv/1' caption='Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, [[3tno]]' pspeed='8'>
 
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== Function ==
== Function ==
'''Transaldolase''' (TAL) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate<ref>PMID:15960612</ref>.
'''Transaldolase''' (TAL) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate<ref>PMID:15960612</ref>.
See also [[Calvin cycle]] and [[Lysine-cysteine NOS bonds]].


== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
TAL overall structure is of a <scene name='47/477090/Cv/2'>TIM barrel</scene> ({{Template:ColorKey_Helix}},
TAL overall structure is of a <scene name='47/477090/Cv/8'>TIM barrel</scene> ({{Template:ColorKey_Helix}},
{{Template:ColorKey_Strand}},
{{Template:ColorKey_Strand}},
{{Template:ColorKey_Loop}},
{{Template:ColorKey_Loop}},
{{Template:ColorKey_Turn}}). The <scene name='47/477090/Cv/5'>active site contains a Schiff-base-bound phosphosugar</scene> at <scene name='47/477090/Cv/6'>Lys135</scene><ref>PMID:24531488</ref>. Water molecules shown as red spheres. <scene name='47/477090/Cv/7'>Cl coordination site</scene>.
{{Template:ColorKey_Turn}}). The <scene name='47/477090/Cv/9'>active site contains a Schiff-base-bound phosphosugar</scene> at <scene name='47/477090/Cv/10'>Lys135</scene><ref>PMID:24531488</ref>. Water molecules are shown as red spheres. <scene name='47/477090/Cv/11'>Cl coordination site</scene>.
== 3D Structures of transaldolase ==
[[Transaldolase 3D structures]]
</StructureSection>
</StructureSection>
== 3D Structures of transaldolase ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Transaldolase
**[[3clm]] – TAL – ''Neisseria gonorrhoeae''<br />
**[[3cwn]],  [[1onr]], [[1ucw]] - EcTAL B – ''Escherichia coli''<br />
**[[3kof]], [[1i2n]], [[1i2o]], [[1i2p]], [[1i2q]], [[1i2r]], [[4rz5]], [[4rz6]] - EcTAL B (mutant)<br />
**[[3hjz]] – TAL B – ''Prochlorococcus marinus''<br />
**[[3igx]], [[4e0c]] – FtTAL B – ''Francisella tularensis''<br />
**[[3m16]] – TAL – ''Oleispira Antarctica''<br />
**[[3r8r]] – TAL – ''Bacillus subtilis''<br />
**[[3r5e]] – TAL – ''Corynebacterium glutamicum''<br />
**[[1f05]] – TAL – human<br />
**[[1vpx]] – TAL – ''Thermotoga maritima''<br />
**[[1wx0]] – TAL – ''Thermus thermophilus''<br />
**[[2cwn]], [[2e1d]] – TAL (mutant) – mouse<br />
*Transaldolase binary complexes
**[[3tk7]] - FtTAL B + fructose 6-phosphate<br />
**[[3te9]] - FtTAL B (mutant) + fructose 6-phosphate<br />
**[[3tkf]] - FtTAL B (mutant) + seduheptulose 7-phosphate<br /`>
**[[3tno]] - FtTAL B + seduheptulose 7-phosphate<br />
**[[3upb]] - FtTAL B + arabinose 5-phosphate<br />
**[[4s2b]] - EcTAL B + tagatose 6-phosphate<br />
**[[4s2c]], [[4s1f]] - EcTAL B + fructose 6-phosphate<br />
**[[4rxf]], [[4rxg]], [[4rz4]] - EcTAL B (mutant) + fructose 6-phosphate<br />
**[[4xz9]] - TAL + glycerol 3-phosphate – ''Thermoplasma acidophilum''<br />
}}


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman