Transaldolase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-{{STRUCTURE_3tno| PDB=3tno  | SIZE=400| SCENE= |right|CAPTION=Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, [[3tno]] }}
+<StructureSection load='' size='400' side='right' scene='47/477090/Cv/1' caption='Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, [[3tno]]' pspeed='8'>
+__TOC__
+== Function ==
+'''Transaldolase''' (TAL) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate<ref>PMID:15960612</ref>.
+See also [[Calvin cycle]] and [[Lysine-cysteine NOS bonds]].
-'''Transaldolase''' (TAD) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate.
+== Disease ==
+TAL deficiency influences mitochondrial homeostasis, Ca+2 fluxing and apoptosis<ref>PMID:18498245</ref>.
-{{TOC limit|limit=2}}
+== Structural highlights ==
+TAL overall structure is of a <scene name='47/477090/Cv/8'>TIM barrel</scene> ({{Template:ColorKey_Helix}},
+{{Template:ColorKey_Strand}},
+{{Template:ColorKey_Loop}},
+{{Template:ColorKey_Turn}}). The <scene name='47/477090/Cv/9'>active site contains a Schiff-base-bound phosphosugar</scene> at <scene name='47/477090/Cv/10'>Lys135</scene><ref>PMID:24531488</ref>. Water molecules are shown as red spheres. <scene name='47/477090/Cv/11'>Cl coordination site</scene>.
 == 3D Structures of transaldolase ==
+[[Transaldolase 3D structures]]
+</StructureSection>
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== References ==
+<references/>
-[[3clm]] – TAD – ''Neisseria gonorrhoeae''<br />
-[[3cwn]],  [[1onr]], [[1ucw]] - EcTAD B – ''Escherichia coli''<br />
-[[3kof]], [[1i2n]], [[1i2o]], [[1i2p]], [[1i2q]], [[1i2r]] - EcTAD B (mutant)<br />
-[[3hjz]] – TAD B – ''Prochlorococcus marinus''<br />
-[[3igx]], [[4e0c]] – FtTAD B – ''Francisella tularensis''<br />
-[[3m16]] – TAD – ''Oleispira Antarctica''<br />
-[[3r8r]] – TAD – ''Bacillus subtilis''<br />
-[[3r5e]] – TAD – ''Corynebacterium glutamicum''<br />
-===Transaldolase binary complexes===
-[[3tk7]] - FtTAD B + fructose 6-phosphate<br />
-[[3te9]] - FtTAD B (mutant) + fructose 6-phosphate<br />
-[[3tkf]] - FtTAD B (mutant) + seduheptulose 7-phosphate<br /`>
-[[3tno]] - FtTAD B + seduheptulose 7-phosphate<br />
-[[3upb]] - FtTAD B + arabinose 5-phosphate<br />
 [[Category:Topic Page]]