Ferredoxin NADP+ Reductase: Difference between revisions
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==Overview== | ==Overview== | ||
[[Image:Ironsulfurferredoxin.png|400px|left|thumb| Ferredoxin NADP<sup>+</sup> Reductase zoomed in (4FK8)]] | [[Image:Ironsulfurferredoxin.png|400px|left|thumb| Ferredoxin NADP<sup>+</sup> Reductase zoomed in (4FK8)]] | ||
<StructureSection load='4FK8' size='340' side='right' caption='FNR protein' scene=''> | <StructureSection load='4FK8' size='340' frame='true' side='right' caption='FNR protein containg FAD (PDB code [[4fk8]])' scene=''> | ||
==Function== | |||
'''Ferredoxin NADP<sup>+</sup> reductase''' [http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] is an enzyme that catalyzes the reduction of NADP<sup>+</sup> to NADPH. This enzyme belongs to a family of enzymes called oxidoreductases[http://en.wikipedia.org/wiki/Oxidoreductase] that contain iron-sulfur proteins as electron donors and NAD<sup>+</sup> or NADP<sup>+</sup> as electron acceptors. FAD, [flavin adenine dinucleotide][http://en.wikipedia.org/wiki/Flavin_adenine_dinucleotide], is also a cofactor of FNR. The ferredoxin NADP<sup>+</sup> reductase participates in a general reaction that proceeds as follows: | '''Ferredoxin NADP<sup>+</sup> reductase''' [http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] is an enzyme that catalyzes the reduction of NADP<sup>+</sup> to NADPH. This enzyme belongs to a family of enzymes called oxidoreductases[http://en.wikipedia.org/wiki/Oxidoreductase] that contain iron-sulfur proteins as electron donors and NAD<sup>+</sup> or NADP<sup>+</sup> as electron acceptors. FAD, [flavin adenine dinucleotide][http://en.wikipedia.org/wiki/Flavin_adenine_dinucleotide], is also a cofactor of FNR. The ferredoxin NADP<sup>+</sup> reductase participates in a general reaction that proceeds as follows: | ||
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==Other Functions== | ==Other Functions== | ||
FNR is also an active protein in plants, and is found in the chloroplast and thylakoid membrane of the cell. The FNR reductive mechanism is responsible for the transfer of the final electrons during photosynthesis from photosystem I to NADPH, which then goes on to participate the Calvin cycle as a reducing cofactor. | FNR is also an active protein in plants, and is found in the chloroplast and thylakoid membrane of the cell. The FNR reductive mechanism is responsible for the transfer of the final electrons during photosynthesis from photosystem I to NADPH, which then goes on to participate the [[Calvin cycle]] as a reducing cofactor. | ||
In other organisms, FNR plays a role in metabolism such as oxidative stress response and steroid metabolism.[http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] | In other organisms, FNR plays a role in metabolism such as oxidative stress response and steroid metabolism.[http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] | ||
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In its active form, the protein is a <scene name='69/699901/Dimeric_fnr/1'>dimer</scene> and contains a [4Fe-4S]<sup>+2</sup> cluster. When inactive, the protein is monomeric and containts a [3Fe-4S]<sup>+2</sup> cluster. FNR in its <scene name='69/699901/Monomeric_fnr/1'>monomer</scene> form can be seen here, with bound NADP and FAD.<ref> PMID: 21166900 </ref> | In its active form, the protein is a <scene name='69/699901/Dimeric_fnr/1'>dimer</scene> and contains a [4Fe-4S]<sup>+2</sup> cluster. When inactive, the protein is monomeric and containts a [3Fe-4S]<sup>+2</sup> cluster. FNR in its <scene name='69/699901/Monomeric_fnr/1'>monomer</scene> form can be seen here, with bound NADP and FAD.<ref> PMID: 21166900 </ref> | ||
== 3D Structures of Ferredoxin NADP+ reductase == | |||
[[Ferredoxin NADP+ Reductase 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||