7oxf: Difference between revisions

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-'''Unreleased structure'''
-The entry 7oxf is ON HOLD  until Paper Publication
+==Solution structure of bee apamin==
+<StructureSection load='7oxf' size='340' side='right'caption='[[7oxf]]' scene=''>
-Authors: Mineev, K., Kuzmenkov, A., Vassilevski, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7oxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OXF FirstGlance]. <br>
-Description: Solution structure of bee apamin
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oxf OCA], [https://pdbe.org/7oxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oxf RCSB], [https://www.ebi.ac.uk/pdbsum/7oxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oxf ProSAT]</span></td></tr>
-[[Category: Mineev, K]]
+</table>
-[[Category: Vassilevski, A]]
+== Function ==
-[[Category: Kuzmenkov, A]]
+[https://www.uniprot.org/uniprot/APAM_APIME APAM_APIME] Neurotoxin that blocks the small-conductance calcium-activated potassium (SK) channels KCa2.1/KCNN1/SK1, KCa2.2/KCNN2/SK2 and KCa2.3/KCNN3/SK3 (PubMed:6122211, PubMed:9459560, PubMed:9287325, PubMed:10696100, PubMed:11533126, PubMed:11212219, PubMed:17142458, PubMed:20562108, PubMed:32560481). Also irreversibly blocks the voltage-gated potassium channel Kv1.3/KCNA3 (IC(50)=13 nM) (PubMed:28108814). Potently blocks human, rat and mouse KCa2.2/KCNN2/SK2 channels (IC(50)=27-140 pM), and moderately blocks human and rat KCa2.3/KCNN3/SK3 channels (IC(50)=0.6-4 nM), and human (IC(50)=0.7-12 nM) and mouse (IC(50)=28 nM) KCa2.1/KCNN1/SK1 channels (PubMed:9459560, PubMed:9287325, PubMed:10696100, PubMed:11533126, PubMed:11212219, PubMed:17142458, PubMed:20562108). However, other reports found that it did not block the human KCa2.1/KCNN1/SK1 channels (PubMed:9287325). Also able to inhibit neuromuscular transmission by a mechanism independent of the blockade of SK channels, which may involve the activation of inhibitory muscarinic M2 receptors on motor nerve terminals (PubMed:19818752).<ref>PMID:10696100</ref> <ref>PMID:11212219</ref> <ref>PMID:11533126</ref> <ref>PMID:17142458</ref> <ref>PMID:19818752</ref> <ref>PMID:20562108</ref> <ref>PMID:28108814</ref> <ref>PMID:32560481</ref> <ref>PMID:6122211</ref> <ref>PMID:9287325</ref> <ref>PMID:9459560</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Apis mellifera]]
+[[Category: Large Structures]]
+[[Category: Kuzmenkov A]]
+[[Category: Mineev K]]
+[[Category: Vassilevski A]]