CREB-binding protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 == Function ==
-'''CREB-binding protein''' (CBP) is a transcription activator.  CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription.  CBP acetylates histones.  It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>
+'''CREB-binding protein''' or '''CREBBP''' (CBP) is a transcription activator.  CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription.  CBP acetylates histones.  It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>
 == Disease ==
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 </StructureSection>
-== 3D Structures of CREB-binding protein ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CBP domains – BZIP 283-341; zinc finger 376-400; KIX 587-673; bromodomain 1081-1197; ZZ 1699-1751; TAZ2 1763-1854
-**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
-**[[2d82]] – hCBP bromodomain  - NMR<br />
-**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain  <br />
-**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain  + inhibitor<br />
-**[[2l84]], [[2l85]] – hCBP bromodomain  + inhibitor - NMR<br />**[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
-**[[1f81]] – mCBP TAZ2 domain - NMR <br />
-**[[1u2n]] – mCBP TAZ1 domain - NMR <br />
-**[[1jjs]] – mCBP IBiD domain - NMR<br />
-**[[1liq]] – mCBP CH1 domain - NMR<br />
-**[[1tot]] – mCBP ZZ domain – NMR <br />
-**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
-*CBP complex with protein
-**[[1zoq]] – hCBP + interferon regulatory factor 3  <br />
-**[[2n1a]] – hCBP  + small ubiquitin-related modifier - NMR<br />
-**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
-**[[2kje]] – hCBP TAZ2 domain  + adenoviral E1A peptide - NMR<br />
-**[[1jsp]] – hCBP bromodomain  + p53 peptide - NMR<br />
-**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
-**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
-**[[2rny]] – hCBP bromodomain  + histone H3 peptide - NMR<br />
-**[[4n3w]], [[4n4f]] - hCBP bromodomain  + histone H4 peptide <br />
-**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain  + ligand<br />
-**[[5zko]] – hCBP BZIP domain + CREB-regulated transcription coactivator + DNA  <br />
-**[[5zk1]] – hCBP BZIP domain (mutant) + CREB-regulated transcription coactivator + DNA  <br />
-**[[1kbh]] – mCBP + nuclear receptor coactivator - NMR <br />
-**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator  - NMR<br />
-**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
-**[[1l8c]] – mCBP TAZ1 domain  + hypoxia-inducible factor 1α - NMR<br />
-**[[2lww]] - mCBP TAZ1 domain  + nuclear transcription factor RELA – NMR <br />
-**[[2ka6]] – mCBP TAZ2 domain  + STAT1-TAD - NMR<br />
-**[[2ka4]] – mCBP TAZ2 domain  + STAT2-TAD - NMR<br />
-**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
-**[[2l14]] – mCBP  nuclear coactivator binding domain + p53 peptide - NMR<br />
-**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
-**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
-**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]